PMID- 16406699
OWN - NLM
STAT- MEDLINE
DCOM- 20060711
LR  - 20061115
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 27
IP  - 3
DP  - 2006 Mar
TI  - Towards an understanding of the transcription factor network of dendritic cell 
      development.
PG  - 140-5
AB  - Dendritic cells (DCs) are antigen-presenting cells of the immune system and 
      develop from hematopoietic stem cells through successive steps of lineage 
      commitment and differentiation. The three major DC populations are epidermal 
      Langerhans cells, tissue/interstitial/dermal DCs and plasmacytoid DCs. We review 
      how gene-targeted mutations in mice have contributed to our understanding of how 
      the various DC subpopulations develop. These studies have revealed both 
      overlapping and distinct pathways of DC differentiation and show that there is no 
      obvious correlation between transcription factor knockout phenotypes and a 
      lymphoid or myeloid origin of DCs.
FAU - Zenke, Martin
AU  - Zenke M
AD  - Department of Cell Biology, Institute for Biomedical Engineering, University 
      Medical School, Rheinisch-Westfalische Technische Hochschule Aachen, 
      Pauwelsstrasse 30, 52074 Aachen, Germany. martin.zenke@rwth-aachen.de
FAU - Hieronymus, Thomas
AU  - Hieronymus T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060110
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*cytology
MH  - Hematopoiesis/*physiology
MH  - Humans
MH  - Mice
MH  - Transcription Factors/*physiology
RF  - 63
EDAT- 2006/01/13 09:00
MHDA- 2006/07/13 09:00
CRDT- 2006/01/13 09:00
PHST- 2005/10/07 00:00 [received]
PHST- 2005/11/14 00:00 [revised]
PHST- 2005/12/15 00:00 [accepted]
PHST- 2006/01/13 09:00 [pubmed]
PHST- 2006/07/13 09:00 [medline]
PHST- 2006/01/13 09:00 [entrez]
AID - S1471-4906(05)00313-3 [pii]
AID - 10.1016/j.it.2005.12.007 [doi]
PST - ppublish
SO  - Trends Immunol. 2006 Mar;27(3):140-5. doi: 10.1016/j.it.2005.12.007. Epub 2006 
      Jan 10.