PMID- 1640694
OWN - NLM
STAT- MEDLINE
DCOM- 19920903
LR  - 20190510
IS  - 0146-4760 (Print)
IS  - 0146-4760 (Linking)
VI  - 16
IP  - 1
DP  - 1992 Jan-Feb
TI  - Distinguishing sympathomimetic amines from amphetamine and methamphetamine in 
      urine by gas chromatography/mass spectrometry.
PG  - 19-27
AB  - Derivatives of seven commonly used sympathomimetic amines and two "designer 
      amines" were isolated from urine, separated chromatographically from amphetamine 
      and methamphetamine, and determined by mass spectrometry with selected ion 
      monitoring. The drugs included ephedrine, propylhexedrine, pseudoephedrine, 
      phenylpropanolamine, hydroxynorephedrine, phenylephrine, phentermine, 
      methylenedioxyamphetamine (MDA), and methylenedioxy methamphetamine (MDMA). The 
      drugs were liquid extracted from urine and derivatized by either 
      heptafluorobutyric anhydride (HFBA) or 4-carbethoxyhexafluorobutyryl chloride 
      (4-CB). Because the base peak ions for ephedrine, pseudoephedrine, 
      propylhexedrine, MDMA, and phentermine are identical to methamphetamine (e.g. 254 
      amu for HFBA) and those for phenylephrine, hydroxynorephedrine, 
      phenylpropanolamine, and MDA are identical to amphetamine (e.g. 240 amu for 
      HFBA), a table of selected ions was developed for all 11 drugs that distinguished 
      amphetamine and methamphetamine from the sympathomimetic amines with either HFBA 
      or 4-CB. The distinguishing ions rely on the ring structure of the different 
      drugs and fragmentation associated with that structure. The 4-CB reagent 
      partially derivatized the hydroxy-containing sympathomimetic amines, while the 
      HFBA completely derivatized all the sympathomimetic amines. Furthermore, false 
      positive results for the 4-CB reagent were found only for methamphetamine 
      (20-2250 ng/mL of methamphetamine) when high concentrations (greater than 5 
      micrograms) of ephedrine or pseudoephedrine were present in the specimen. These 
      results are related to a combination of injection port temperature and 
      cleanliness of the injection port sleeve.
FAU - Thurman, E M
AU  - Thurman EM
AD  - Clinical Reference Laboratory, Lenexa, Kansas 66214.
FAU - Pedersen, M J
AU  - Pedersen MJ
FAU - Stout, R L
AU  - Stout RL
FAU - Martin, T
AU  - Martin T
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Fluorocarbons)
RN  - 0 (Sympathomimetics)
RN  - 18381-53-8 (4-carbethoxyhexafluorobutyryl chloride)
RN  - 336-59-4 (heptafluorobutyric anhydride)
RN  - 44RAL3456C (Methamphetamine)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/*urine
MH  - False Positive Reactions
MH  - Fluorocarbons
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Methamphetamine/*urine
MH  - Sympathomimetics/*urine
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1093/jat/16.1.19 [doi]
PST - ppublish
SO  - J Anal Toxicol. 1992 Jan-Feb;16(1):19-27. doi: 10.1093/jat/16.1.19.