PMID- 16412036
OWN - NLM
STAT- MEDLINE
DCOM- 20060725
LR  - 20161124
IS  - 1443-9611 (Print)
IS  - 1443-9573 (Linking)
VI  - 7
IP  - 1
DP  - 2006
TI  - Serous cystic neoplasms of the pancreas: a clinicopathologic and 
      immunohistochemical analysis.
PG  - 39-44
AB  - OBJECTIVE: To clarify whether the various subtypes of serous cystic neoplasms 
      (SCNs) of the pancreas can be distinguished from each other by marker profiles. 
      METHODS: The immunoprofiles of 13 SCNs were defined by using antibodies against 
      cytoskeletal, neuroendocrine, hormone receptor, and mucin markers. In addition, 
      we examined the expression of calrentinin and alpha-inhibin. RESULTS: SCN 
      included 7 cases of serous microcystic adenomas (SMA), 3 cases of serous 
      oligocystic ill-defined adenomas (SOIA), 1 case of solid serous adenoma (SSA), 1 
      case of von Hippel-Lindau-associated cystic neoplasm (VHL-CN), and 1 case of 
      serous cystadenocarcinoma (SCC). These neoplasms are histologically similar, but 
      differ in their localization, gross appearance, gender distribution, and 
      biological behavior. The various types of SCNs showed a very similar 
      immunoprofile, characterized by positivity for cytokeratins (100%) and negativity 
      for vimentin and synaptophysin. Other markers that were commonly expressed in the 
      SCNs were alpha-inhibin (85%), MUC1 (69%) and MUC6 (77%). CONCLUSION: The results 
      suggest that, despite their biologic differences, the various types of SCNs have 
      the same (or a very similar) cell type and may therefore have a common direction 
      of differentiation. A centroacinar origin is supported by the finding that a 
      number of SCNs share MUC1 and MUC6 expression with pancreatic centroacinar cells. 
      Alpha-inhibin, and MUC6 may be regarded as new markers for this type of 
      pancreatic tumor.
FAU - Ji, Yuan
AU  - Ji Y
AD  - Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China. 
      yji@zshospital.com
FAU - Wang, Xiu Nan
AU  - Wang XN
FAU - Lou, Wen Hui
AU  - Lou WH
FAU - Sujie, Akesu
AU  - Sujie A
FAU - Tan, Yun Shan
AU  - Tan YS
FAU - Jin, Da Yong
AU  - Jin DY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Retracted Publication
PL  - Australia
TA  - Chin J Dig Dis
JT  - Chinese journal of digestive diseases
JID - 101088612
RN  - 0 (Biomarkers, Tumor)
SB  - IM
RIN - Xiao SD. Chin J Dig Dis. 2006;7(4):246. PMID: 17054588
MH  - Adult
MH  - Biomarkers, Tumor
MH  - Cystadenoma, Serous/diagnostic imaging/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Neoplasms/diagnostic imaging/*pathology
MH  - Tomography, X-Ray Computed
EDAT- 2006/01/18 09:00
MHDA- 2006/07/26 09:00
CRDT- 2006/01/18 09:00
PHST- 2006/01/18 09:00 [pubmed]
PHST- 2006/07/26 09:00 [medline]
PHST- 2006/01/18 09:00 [entrez]
AID - CDD [pii]
AID - 10.1111/j.1443-9573.2006.00242.x [doi]
PST - ppublish
SO  - Chin J Dig Dis. 2006;7(1):39-44. doi: 10.1111/j.1443-9573.2006.00242.x.