PMID- 16412507
OWN - NLM
STAT- MEDLINE
DCOM- 20061003
LR  - 20061115
IS  - 0145-305X (Print)
IS  - 0145-305X (Linking)
VI  - 30
IP  - 9
DP  - 2006
TI  - Identification and characterization of a myeloid differentiation factor 88 
      (MyD88) cDNA and gene in Japanese flounder, Paralichthys olivaceus.
PG  - 807-16
AB  - The interleukin-1 receptor/toll-like receptor (IL-1R/TLR) superfamily signaling 
      involves myeloid differentiation factor 88 (MyD88) that acts as an important 
      adapter protein. A Japanese flounder (Paralichthys olivaceus) MyD88 (jfMyD88) 
      cDNA and gene were cloned, and found to have lengths of 1.5 and 3.01 kb, 
      respectively. The ORF encodes 285 amino acids that contain a death domain and a 
      Toll/IL-1 receptor domain. The gene is composed of 5 exons and 4 introns. The 
      jfMyD88 gene is highly expressed in organs involved in immune functions, 
      including the gills, intestines, kidney, skin and spleen. Three days after a fish 
      was infected with Edwardsiella tarda, staining with anti-jfMyD88 polyclonal 
      antibody revealed an increased population of MyD88-positive cells in the kidney 
      and spleen. These results imply that MyD88 has an important role in the innate 
      immune system in Japanese flounder.
FAU - Takano, Tomokazu
AU  - Takano T
AD  - Laboratory of Genome Science, Graduate School of Marine Science and Technology, 
      Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 
      108-8477, Japan.
FAU - Kondo, Hidehiro
AU  - Kondo H
FAU - Hirono, Ikuo
AU  - Hirono I
FAU - Saito-Taki, Tatsuo
AU  - Saito-Taki T
FAU - Endo, Makoto
AU  - Endo M
FAU - Aoki, Takashi
AU  - Aoki T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051213
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/biosynthesis/genetics/*immunology
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Western/veterinary
MH  - Edwardsiella tarda/*immunology
MH  - Enterobacteriaceae Infections/immunology/*veterinary
MH  - Fish Diseases/*immunology/microbiology
MH  - Flounder/*genetics/immunology
MH  - Immunohistochemistry/veterinary
MH  - Kidney/immunology/microbiology
MH  - Molecular Sequence Data
MH  - Myeloid Differentiation Factor 88
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction/veterinary
MH  - Sequence Alignment
MH  - Spleen/immunology/microbiology
EDAT- 2006/01/18 09:00
MHDA- 2006/10/04 09:00
CRDT- 2006/01/18 09:00
PHST- 2005/08/16 00:00 [received]
PHST- 2005/11/16 00:00 [revised]
PHST- 2005/11/16 00:00 [accepted]
PHST- 2006/01/18 09:00 [pubmed]
PHST- 2006/10/04 09:00 [medline]
PHST- 2006/01/18 09:00 [entrez]
AID - S0145-305X(05)00222-3 [pii]
AID - 10.1016/j.dci.2005.11.003 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2006;30(9):807-16. doi: 10.1016/j.dci.2005.11.003. Epub 2005 
      Dec 13.