PMID- 16412785
OWN - NLM
STAT- MEDLINE
DCOM- 20060516
LR  - 20160422
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 43
IP  - 1
DP  - 2006 Jan
TI  - Genetics of risk factors for graft-versus-host disease.
PG  - 11-23
AB  - Modern understanding of the genetic basis of graft-versus-host disease (GVHD) in 
      allogeneic hematopoietic stem cell transplantation (HSCT) involves knowledge of 
      human leukocyte antigen (HLA), killer immunoglobulin-like receptors (KIR), 
      cytokine genes, and their interactions. Insights into the immunogenetic basis of 
      GVHD come from long-standing clinical experience in the use of myeloablative 
      conditioning regimens and donor bone marrow as the grafting source. Under these 
      circumstances, donor T-cell recognition of host HLA can cause GVHD. The recent 
      elucidation of HLA class I as ligands for natural killer (NK) cell inhibitory KIR 
      demonstrates that GVHD is the result of a complex interplay between the innate 
      and adaptive immune responses. The extent to which T cells and NK cells 
      contribute to clinical GVHD is a function of the host post-conditioning 
      environment, immunosuppressive treatments, and the content of the graft source. 
      The contribution of donor and host genetic differences in cytokine genes in 
      modulating risks of GVHD has recently been recognized.
FAU - Petersdorf, Effie W
AU  - Petersdorf EW
AD  - Department of Medicine, University of Washington, Seattle, WA 98109, USA. 
      epetersd@fhcrc.org
FAU - Malkki, Mari
AU  - Malkki M
LA  - eng
GR  - AI33484/AI/NIAID NIH HHS/United States
GR  - AI49213/AI/NIAID NIH HHS/United States
GR  - CA100019/CA/NCI NIH HHS/United States
GR  - CA15704/CA/NCI NIH HHS/United States
GR  - CA18029/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Cytokines/genetics/immunology
MH  - Genetic Predisposition to Disease
MH  - Graft vs Host Disease/*genetics/immunology
MH  - HLA Antigens/genetics/immunology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Receptors, Immunologic/genetics/immunology
MH  - Receptors, KIR
RF  - 82
EDAT- 2006/01/18 09:00
MHDA- 2006/05/17 09:00
CRDT- 2006/01/18 09:00
PHST- 2006/01/18 09:00 [pubmed]
PHST- 2006/05/17 09:00 [medline]
PHST- 2006/01/18 09:00 [entrez]
AID - S0037-1963(05)00167-8 [pii]
AID - 10.1053/j.seminhematol.2005.09.002 [doi]
PST - ppublish
SO  - Semin Hematol. 2006 Jan;43(1):11-23. doi: 10.1053/j.seminhematol.2005.09.002.