PMID- 16412786
OWN - NLM
STAT- MEDLINE
DCOM- 20060516
LR  - 20220330
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 43
IP  - 1
DP  - 2006 Jan
TI  - The clinical spectrum of acute graft-versus-host disease.
PG  - 24-31
AB  - Acute graft-versus-host disease (GVHD), initiated by the reaction of donor T 
      lymphocytes against nonshared recipient antigens, typically leads to a clinical 
      syndrome characterized by cutaneous eruptions and intestinal and hepatic 
      dysfunction. These three organ systems are considered in the clinical grading of 
      acute GVHD. However, other targets may be involved. With conventional transplant 
      conditioning regimens and in vivo prophylaxis, GVHD becomes clinically manifest 
      within 2 to 4 weeks. With reduced-intensity conditioning, the onset of acute GVHD 
      may be delayed until 2 to 3 months after transplantation. Hyperacute GVHD may 
      occur within a week of transplantation after severely human leukocyte antigen 
      (HLA)-mismatched transplants or transplants without GVHD prophylaxis. There is no 
      reliable laboratory test for acute GVHD, and the diagnosis is based on clinical 
      assessment.
FAU - Deeg, H Joachim
AU  - Deeg HJ
AD  - Fred Hutchinson Cancer Research Center, Seattle WA 98109-1024, USA. 
      jdeeg@fhcrc.org
FAU - Antin, Joseph H
AU  - Antin JH
LA  - eng
GR  - CA15704/CA/NCI NIH HHS/United States
GR  - CA18029/CA/NCI NIH HHS/United States
GR  - HL36444/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
SB  - IM
MH  - Acute Disease
MH  - Graft vs Host Disease/*diagnosis/pathology
MH  - Humans
RF  - 83
EDAT- 2006/01/18 09:00
MHDA- 2006/05/17 09:00
CRDT- 2006/01/18 09:00
PHST- 2006/01/18 09:00 [pubmed]
PHST- 2006/05/17 09:00 [medline]
PHST- 2006/01/18 09:00 [entrez]
AID - S0037-1963(05)00168-X [pii]
AID - 10.1053/j.seminhematol.2005.09.003 [doi]
PST - ppublish
SO  - Semin Hematol. 2006 Jan;43(1):24-31. doi: 10.1053/j.seminhematol.2005.09.003.