PMID- 16413497
OWN - NLM
STAT- MEDLINE
DCOM- 20060418
LR  - 20220309
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 341
IP  - 2
DP  - 2006 Mar 10
TI  - Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk 
      in Chinese population.
PG  - 310-3
AB  - OBJECTIVE: The aims of the present study were to assess whether the glutathione 
      S-transferase T1 (GSTT1), M1 (GSTM1), and NAD(P)H: quinone oxidoreductase 1 
      (NQO1) genotypes are associated with type 2 diabetes mellitus (T2 DM) and to 
      ascertain whether the levels of blood lipids given exposure to diabetes are 
      modified by the specific genetic polymorphisms of GSTT1, GSTM1, and NQO1. 
      METHODS: This case-control study was conducted on 200 subjects. The genotypes 
      were determined using a polymerase chain reaction (PCR) and PCR-restriction 
      fragment length polymorphism. RESULTS: The GSTT1-present genotype conferred a 
      statistically significant 0.49-fold reduction in risk of T2 DM relative to the 
      null genotype. Individuals with GSTT1-null or GSTM1-null genotype had higher 
      levels of low-density-lipoprotein cholesterol, apolipoprotein B, and 
      lipoprotein(a), respectively. There was no association between either GSTM1 or 
      NQO1 polymorphism and risk of T2 DM. CONCLUSION: The present results suggest that 
      the GSTT1 gene may contribute to the development of T2 DM and may be one of the 
      candidate genes of T2 DM in Chinese population.
FAU - Wang, Guoying
AU  - Wang G
AD  - Department of Endocrinology, Peking University Third Hospital, Beijing 100083, PR 
      China. wangguoying@medmail.com.cn
FAU - Zhang, Lu
AU  - Zhang L
FAU - Li, Qiongfang
AU  - Li Q
LA  - eng
PT  - Journal Article
DEP - 20060110
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Blood Glucose)
RN  - 9007-49-2 (DNA)
RN  - EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone))
RN  - EC 1.6.5.2 (NQO1 protein, human)
RN  - EC 2.5.1.- (glutathione S-transferase T1)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 2.5.1.18 (glutathione S-transferase M1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - China
MH  - DNA/metabolism
MH  - Diabetes Mellitus, Type 2/*diagnosis/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Glutathione Transferase/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - NAD(P)H Dehydrogenase (Quinone)/*genetics
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Risk
EDAT- 2006/01/18 09:00
MHDA- 2006/04/19 09:00
CRDT- 2006/01/18 09:00
PHST- 2005/12/26 00:00 [received]
PHST- 2005/12/29 00:00 [accepted]
PHST- 2006/01/18 09:00 [pubmed]
PHST- 2006/04/19 09:00 [medline]
PHST- 2006/01/18 09:00 [entrez]
AID - S0006-291X(06)00037-4 [pii]
AID - 10.1016/j.bbrc.2005.12.195 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2006 Mar 10;341(2):310-3. doi: 
      10.1016/j.bbrc.2005.12.195. Epub 2006 Jan 10.