PMID- 16415327
OWN - NLM
STAT- MEDLINE
DCOM- 20060622
LR  - 20151119
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 90
IP  - 2
DP  - 2006 Apr
TI  - Effects of perfluorooctanoic acid exposure during pregnancy in the mouse.
PG  - 510-8
AB  - Perfluorooctanoic acid (PFOA), a member of the perfluoroalkyl acids that have 
      wide commercial applications, has recently been detected in humans and wildlife. 
      The current study characterizes the developmental toxicity of PFOA in the mouse. 
      Timed-pregnant CD-1 mice were given 1, 3, 5, 10, 20, or 40 mg/kg PFOA by oral 
      gavage daily from gestational day (GD) 1 to 17; controls received an equivalent 
      volume (10 ml/kg) of water. PFOA treatment produced dose-dependent full-litter 
      resorptions; all dams in the 40-mg/kg group resorbed their litters. Weight gain 
      in dams that carried pregnancy to term was significantly lower in the 20-mg/kg 
      group. At GD 18, some dams were sacrificed for maternal and fetal examinations 
      (group A), and the rest were treated once more with PFOA and allowed to give 
      birth (group B). Postnatal survival, growth, and development of the offspring 
      were monitored. PFOA induced enlarged liver in group A dams at all dosages, but 
      did not alter the number of implantations. The percent of live fetuses was lower 
      only in the 20-mg/kg group (74 vs. 94% in controls), and fetal weight was also 
      significantly lower in this group. However, no significant increase in 
      malformations was noted in any treatment group. The incidence of live birth in 
      group B mice was significantly lowered by PFOA: ca. 70% for the 10- and 20-mg/kg 
      groups compared to 96% for controls. Postnatal survival was severely compromised 
      at 10 or 20 mg/kg, and moderately so at 5 mg/kg. Dose-dependent growth deficits 
      were detected in all PFOA-treated litters except the 1-mg/kg group. Significant 
      delays in eye-opening (up to 2-3 days) were noted at 5 mg/kg and higher dosages. 
      Accelerated sexual maturation was observed in male offspring, but not in females. 
      These data indicate maternal and developmental toxicity of PFOA in the mouse, 
      leading to early pregnancy loss, compromised postnatal survival, delays in 
      general growth and development, and sex-specific alterations in pubertal 
      maturation.
FAU - Lau, Christopher
AU  - Lau C
AD  - Reproductive Toxicology Division, National Health and Environmental Effects 
      Research Laboratory, U.S. Environmental Protection Agency, Research Triangle 
      Park, North Carolina 27711, USA. lau.christopher@epa.gov
FAU - Thibodeaux, Julie R
AU  - Thibodeaux JR
FAU - Hanson, Roger G
AU  - Hanson RG
FAU - Narotsky, Michael G
AU  - Narotsky MG
FAU - Rogers, John M
AU  - Rogers JM
FAU - Lindstrom, Andrew B
AU  - Lindstrom AB
FAU - Strynar, Mark J
AU  - Strynar MJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20060116
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Caprylates)
RN  - 0 (Fluorocarbons)
RN  - 947VD76D3L (perfluorooctanoic acid)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*growth & development
MH  - Caprylates/blood/pharmacokinetics/*toxicity
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Fluorocarbons/blood/pharmacokinetics/*toxicity
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sex Factors
MH  - Species Specificity
EDAT- 2006/01/18 09:00
MHDA- 2006/06/23 09:00
CRDT- 2006/01/18 09:00
PHST- 2006/01/18 09:00 [pubmed]
PHST- 2006/06/23 09:00 [medline]
PHST- 2006/01/18 09:00 [entrez]
AID - kfj105 [pii]
AID - 10.1093/toxsci/kfj105 [doi]
PST - ppublish
SO  - Toxicol Sci. 2006 Apr;90(2):510-8. doi: 10.1093/toxsci/kfj105. Epub 2006 Jan 16.