PMID- 16417740
OWN - NLM
STAT- MEDLINE
DCOM- 20060320
LR  - 20190917
IS  - 1472-6483 (Print)
IS  - 1472-6483 (Linking)
VI  - 11
IP  - 6
DP  - 2005 Dec
TI  - Treatment of recurrent IVF failure and human leukocyte antigen similarity by 
      intravenous immunoglobulin.
PG  - 745-9
AB  - This study sought to assess the efficacy of intravenous immunoglobulin (IVIg) in 
      improving pregnancy rates and outcome, in a select group of patients with 
      repeated IVF failure and human leukocyte antigen (HLA) similarity. Couples 
      suffering from recurrent IVF failure, defined as at least seven attempts at 
      embryo transfer with no successful implantations, who were found to share at 
      least three HLA loci, and a negative cross-match test, were included in the 
      study. The treatment consisted of two 30 g IVIg doses: one before oocyte 
      retrieval, and a second as soon as a fetal pulse was identified on ultrasound. 
      Ten couples comprised the study group. In total, these couples had undergone 98 
      IVF cycles with no successful pregnancies prior to initiation of the study. 
      Following a total of 18 IVIg courses, seven women conceived, two women twice. Up 
      to date, five women have delivered at least one live fetus, at 27 weeks or later. 
      One woman is currently in the early third trimester of a twin pregnancy, and one 
      woman had a late abortion at 19 weeks. The results suggest that couples with 
      recurrent IVF failure and HLA similarity, may benefit from IVIg treatment.
FAU - Elram, T
AU  - Elram T
AD  - Department of Obstetrics and Gynecology, Hadassah University Hospital, Ein Kerem, 
      Jerusalem, Israel. coren-elram@barak-online.net
FAU - Simon, A
AU  - Simon A
FAU - Israel, S
AU  - Israel S
FAU - Revel, A
AU  - Revel A
FAU - Shveiky, D
AU  - Shveiky D
FAU - Laufer, N
AU  - Laufer N
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Adult
MH  - Female
MH  - *Fertilization in Vitro
MH  - *HLA Antigens
MH  - Histocompatibility Antigens Class I
MH  - Histocompatibility Antigens Class II
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Infant, Newborn
MH  - Infertility/*immunology/*therapy
MH  - Male
MH  - Pregnancy
MH  - Pregnancy Maintenance/immunology
MH  - Recurrence
MH  - Treatment Failure
EDAT- 2006/01/19 09:00
MHDA- 2006/03/21 09:00
CRDT- 2006/01/19 09:00
PHST- 2006/01/19 09:00 [pubmed]
PHST- 2006/03/21 09:00 [medline]
PHST- 2006/01/19 09:00 [entrez]
AID - S1472-6483(10)61694-X [pii]
AID - 10.1016/s1472-6483(10)61694-x [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2005 Dec;11(6):745-9. doi: 10.1016/s1472-6483(10)61694-x.