PMID- 16421119
OWN - NLM
STAT- MEDLINE
DCOM- 20060313
LR  - 20181113
IS  - 0022-3050 (Print)
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 77
IP  - 2
DP  - 2006 Feb
TI  - Serum matrix metalloproteinase-3 levels correlate with disease activity in 
      relapsing-remitting multiple sclerosis.
PG  - 185-8
AB  - BACKGROUND: Adhesion molecules and matrix metalloproteinases (MMPs) are known to 
      be relevant to the ongoing development and disappearance of areas of 
      demyelination in the white matter of the CNS of multiple sclerosis (MS) patients. 
      This study examined whether serum matrix metalloproteinase-3 (MMP-3) levels 
      correlate with disease activity in MS. METHODS: Serum MMP-3 levels in 47 
      consecutive patients with relapsing-remitting MS were measured by immunoassay 
      every 4 weeks over a 15 month period. RESULTS: During the study period, 48 
      clinical relapses occurred. Serum MMP-3 levels within 1 month of relapse were 
      significantly higher than during the remission phase. Sequential analysis showed 
      that serum MMP-3 levels had increased transiently at the time of clinical relapse 
      but returned to the normal range within a month. CONCLUSIONS: Circulatory MMP-3 
      levels are correlated with disease activity in relapsing-remitting MS. This may 
      contribute to the breakdown of the blood-brain barrier at the time of relapse.
FAU - Kanesaka, T
AU  - Kanesaka T
AD  - Department of Neurology, Chiba University School of Medicine, 1-8-1, Inohana, 
      Chuo-ku, Chiba, 260-8670 Japan. kane2000@f7.dion.ne.jp
FAU - Mori, M
AU  - Mori M
FAU - Hattori, T
AU  - Hattori T
FAU - Oki, T
AU  - Oki T
FAU - Kuwabara, S
AU  - Kuwabara S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Biomarkers)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Matrix Metalloproteinase 1/blood
MH  - Matrix Metalloproteinase 2/blood
MH  - Matrix Metalloproteinase 3/*blood
MH  - Matrix Metalloproteinase 9/blood
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*enzymology
MH  - Neurologic Examination
MH  - Reference Values
MH  - Statistics as Topic
PMC - PMC2077579
COIS- Competing interests: none declared
EDAT- 2006/01/20 09:00
MHDA- 2006/03/15 09:00
PMCR- 2009/02/01
CRDT- 2006/01/20 09:00
PHST- 2006/01/20 09:00 [pubmed]
PHST- 2006/03/15 09:00 [medline]
PHST- 2006/01/20 09:00 [entrez]
PHST- 2009/02/01 00:00 [pmc-release]
AID - 77/2/185 [pii]
AID - jn68619 [pii]
AID - 10.1136/jnnp.2005.068619 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):185-8. doi: 
      10.1136/jnnp.2005.068619.