PMID- 16423161 OWN - NLM STAT- MEDLINE DCOM- 20060802 LR - 20061115 IS - 0001-690X (Print) IS - 0001-690X (Linking) VI - 113 IP - 2 DP - 2006 Feb TI - Neuropsychological functions predict 1- and 3-year outcome in first-episode psychosis. PG - 102-11 AB - OBJECTIVE: To examine neuropsychological performance as a possible predictor of course and outcome in first-episode psychotic (FEP) patients. METHOD: A group of consecutive FEP patients (n = 120) tested with Wechsler Adult Intelligence Scales-Revised (WAIS-R) at baseline was compared with a healthy group (n = 30) matched for age, education and gender. Relationship between WAIS-R and both Brief Psychiatric Rating Scale and Global Assessment of Function (GAF) ratings were studied at baseline and at 1- and 3-year follow-ups. RESULTS: The performance of FEP patients was significantly lower (P < 0.001) than that of healthy comparison subjects on all WAIS-R subtests except for Information and Comprehension. The WAIS-R scores of patients with schizophrenia syndromes (DSM-IV) were lower than those of patients with non-schizophrenia syndromes on Block Design. Low WAIS-R Full-Scale IQ scores in FEP patients predicted the presence of negative symptoms at 1-year follow-up and of low GAF ratings at 3-year follow-up. CONCLUSION: Neurocognitive performance at admission appears to predict various aspects of functional outcome in FEP. FAU - Carlsson, R AU - Carlsson R AD - Department of Psychology, Lund University, Lund, Sweden. roger.carlsson@ltkronoberg.se FAU - Nyman, H AU - Nyman H FAU - Ganse, G AU - Ganse G FAU - Cullberg, J AU - Cullberg J LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Acta Psychiatr Scand JT - Acta psychiatrica Scandinavica JID - 0370364 RN - 0 (Antipsychotic Agents) SB - IM MH - Adolescent MH - Adult MH - Antipsychotic Agents/administration & dosage MH - Brief Psychiatric Rating Scale/statistics & numerical data MH - Cognition Disorders/*diagnosis/psychology/therapy MH - Cohort Studies MH - Combined Modality Therapy MH - Comorbidity MH - Dose-Response Relationship, Drug MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Patient Admission MH - Predictive Value of Tests MH - Psychometrics/statistics & numerical data MH - Psychotic Disorders/*diagnosis/psychology/therapy MH - Remission Induction MH - Schizophrenia/*diagnosis/therapy MH - Sensitivity and Specificity MH - Wechsler Scales/*statistics & numerical data EDAT- 2006/01/21 09:00 MHDA- 2006/08/03 09:00 CRDT- 2006/01/21 09:00 PHST- 2006/01/21 09:00 [pubmed] PHST- 2006/08/03 09:00 [medline] PHST- 2006/01/21 09:00 [entrez] AID - ACP661 [pii] AID - 10.1111/j.1600-0447.2005.00661.x [doi] PST - ppublish SO - Acta Psychiatr Scand. 2006 Feb;113(2):102-11. doi: 10.1111/j.1600-0447.2005.00661.x.