PMID- 16423167
OWN - NLM
STAT- MEDLINE
DCOM- 20060802
LR  - 20151119
IS  - 0001-690X (Print)
IS  - 0001-690X (Linking)
VI  - 113
IP  - 2
DP  - 2006 Feb
TI  - Patients with schizophrenia treated with aripiprazole, a multicentre naturalistic 
      study.
PG  - 148-53
AB  - OBJECTIVE: The purpose was to carry out a naturalistic study on efficacy, safety 
      and tolerability of aripiprazole during treatment of schizophrenia. Fifty-one 
      patients with an ICD-10 diagnosis of schizophrenia and partial responders to 
      prior antipsychotic medication were offered treatment with aripiprazole as 
      monotherapy or in combination their prior medication. Inclusion criteria were 
      lack of therapeutic effect or adverse events on former antipsychotic treatment. 
      METHOD: Six-month open multicentre naturalistic study with prospective 
      assessments including Body Mass Index (BMI), Clinical Global Impression-Severity 
      (CGI-S), Clinical Global Impression-Improvement, Global Assessment of Functioning 
      Scale (GAF) and adverse events. RESULTS: A statistically significant improvement 
      in the different measures of psychopathology and global functioning (CGI-S 
      reduction 34.7%; GAF improvement 14%) was shown in combination with a 
      statistically significant reduction in BMI of 2.9%. Nine patients (17.6%) did not 
      complete the 6-month treatment. CONCLUSION: In an open multicentre naturalistic 
      study, aripiprazole showed to improve the severity of psychotic symptoms and the 
      global level of functioning. However, many of the patients (47%) were also given 
      another antipsychotic drug at the same time. Also, high compliance and few side 
      effects were reported. However, because of the study design, the results must be 
      interpreted conservatively.
FAU - Christensen, A F
AU  - Christensen AF
AD  - Vejle General Hospital, Vejle, Denmark.
FAU - Poulsen, J
AU  - Poulsen J
FAU - Nielsen, C T
AU  - Nielsen CT
FAU - Bork, B
AU  - Bork B
FAU - Christensen, A
AU  - Christensen A
FAU - Christensen, M
AU  - Christensen M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Acta Psychiatr Scand
JT  - Acta psychiatrica Scandinavica
JID - 0370364
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Piperazines)
RN  - 0 (Quinolones)
RN  - 82VFR53I78 (Aripiprazole)
SB  - IM
CIN - Acta Psychiatr Scand. 2006 Oct;114(4):294; author reply 294. PMID: 16968370
MH  - Activities of Daily Living/classification/psychology
MH  - Adult
MH  - Analysis of Variance
MH  - Antipsychotic Agents/adverse effects/*therapeutic use
MH  - Aripiprazole
MH  - Body Mass Index
MH  - Denmark
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Piperazines/adverse effects/*therapeutic use
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Psychometrics/statistics & numerical data
MH  - Quinolones/adverse effects/*therapeutic use
MH  - Schizophrenia/diagnosis/*drug therapy
MH  - Treatment Outcome
EDAT- 2006/01/21 09:00
MHDA- 2006/08/03 09:00
CRDT- 2006/01/21 09:00
PHST- 2006/01/21 09:00 [pubmed]
PHST- 2006/08/03 09:00 [medline]
PHST- 2006/01/21 09:00 [entrez]
AID - ACP736 [pii]
AID - 10.1111/j.1600-0447.2005.00736.x [doi]
PST - ppublish
SO  - Acta Psychiatr Scand. 2006 Feb;113(2):148-53. doi: 
      10.1111/j.1600-0447.2005.00736.x.