PMID- 16423552
OWN - NLM
STAT- MEDLINE
DCOM- 20060828
LR  - 20091119
IS  - 1357-2725 (Print)
IS  - 1357-2725 (Linking)
VI  - 38
IP  - 7
DP  - 2006
TI  - Jun signalling in the epidermis: From developmental defects to psoriasis and skin 
      tumors.
PG  - 1043-9
AB  - The Jun proteins Jun, JunB and JunD are core members of activator protein-1 
      (AP-1), a dimeric transcription factor complex consisting of homo- and 
      heterodimers of the Jun, Fos, activating transcription factor (ATF) and 
      musculoaponeurotic fibrosarcoma (Maf) families. Growth factors, hormones and a 
      variety of environmental stresses activate mitogen activated protein kinase 
      (MAPK) cascades that enhance Jun/AP-1 activity, e.g. through phosphorylation 
      thereby regulating cell proliferation, differentiation, transformation and/or 
      apoptosis. Embryonic lethality of various AP-1 knock-outs, e.g. for Jun, JunB, 
      Fra-1 and Fra-2 largely prevented functional studies in vivo. Therefore, 
      conditional knock-out strategies, in particular for the epidermis, have become an 
      important model to study the regulation and function of AP-1 subunits in 
      physiological and pathological processes in vivo. Jun is regarded as a positive 
      regulator of keratinocyte proliferation/differentiation during development and in 
      skin cancer through its direct transcriptional effect on epidermal growth factor 
      receptor (EGFR) expression. In contrast, JunB can antagonize proliferation of 
      keratinocytes and hematopoietic stem cells. Furthermore, it has been demonstrated 
      in patient's samples and an inducible mouse model that down-regulation of 
      JunB/AP-1 in keratinocytes is one initiating event in the aetiology of psoriasis 
      which is characterized by increased cell proliferation and deregulated cytokine 
      expression.
FAU - Zenz, Rainer
AU  - Zenz R
AD  - Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 
      Vienna, Austria. rainer.zenz@lbicr.lbg.ac.at
FAU - Wagner, Erwin F
AU  - Wagner EF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20051220
PL  - Netherlands
TA  - Int J Biochem Cell Biol
JT  - The international journal of biochemistry & cell biology
JID - 9508482
RN  - 0 (Activating Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Transcription Factor AP-1)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 1)
SB  - IM
MH  - Activating Transcription Factors/metabolism
MH  - Animals
MH  - DNA-Binding Proteins/metabolism
MH  - Developmental Biology
MH  - Epidermis/*metabolism
MH  - Humans
MH  - Keratinocytes/metabolism
MH  - MAP Kinase Kinase 1/metabolism
MH  - Mice
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Proto-Oncogene Proteins c-jun/*metabolism
MH  - Psoriasis/*physiopathology
MH  - Signal Transduction/physiology
MH  - Skin Neoplasms/*physiopathology
MH  - Transcription Factor AP-1/metabolism
MH  - Transcription Factors/metabolism
RF  - 40
EDAT- 2006/01/21 09:00
MHDA- 2006/08/29 09:00
CRDT- 2006/01/21 09:00
PHST- 2005/09/28 00:00 [received]
PHST- 2005/11/16 00:00 [revised]
PHST- 2005/11/21 00:00 [accepted]
PHST- 2006/01/21 09:00 [pubmed]
PHST- 2006/08/29 09:00 [medline]
PHST- 2006/01/21 09:00 [entrez]
AID - S1357-2725(05)00391-2 [pii]
AID - 10.1016/j.biocel.2005.11.011 [doi]
PST - ppublish
SO  - Int J Biochem Cell Biol. 2006;38(7):1043-9. doi: 10.1016/j.biocel.2005.11.011. 
      Epub 2005 Dec 20.