PMID- 16423576
OWN - NLM
STAT- MEDLINE
DCOM- 20060801
LR  - 20060120
IS  - 0021-9975 (Print)
IS  - 0021-9975 (Linking)
VI  - 134
IP  - 1
DP  - 2006 Jan
TI  - Brain lesions in pigs dually infected with porcine reproductive and respiratory 
      syndrome virus and pseudorabies virus.
PG  - 111-4
AB  - Four pigs were inoculated with an aerosol containing porcine reproductive and 
      respiratory syndrome virus (PRRSV) followed 14 days later by inoculation with 
      pseudorabies virus (PRV). The four dually infected pigs showed severe clinical 
      signs, and one died on day 6 after infection with PRV. As demonstrated 
      previously, the clinical disease was much more severe than that produced by 
      either virus alone. All four dually infected pigs developed severe 
      non-suppurative encephalitis, two had tonsillitis, two had necrotizing 
      bronchiolitis, and one had lymphadenitis. The distribution of lesions 
      corresponded closely with the detection of intranuclear inclusion bodies and PRV 
      antigen. High numbers of TUNEL-positive cells detected in the thymus were 
      associated with thymic atrophy.
FAU - Narita, M
AU  - Narita M
AD  - National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki 305-0856, Japan.
FAU - Ishi, M
AU  - Ishi M
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Brain/*pathology
MH  - Disease Models, Animal
MH  - Encephalitis, Viral/pathology
MH  - Encephalomalacia/pathology/veterinary/virology
MH  - In Situ Nick-End Labeling
MH  - Porcine Reproductive and Respiratory Syndrome/*pathology
MH  - Pseudorabies/complications/*pathology/transmission
MH  - Random Allocation
MH  - Swine
MH  - Swine Diseases/*pathology
MH  - T-Lymphocytes/pathology
EDAT- 2006/01/21 09:00
MHDA- 2006/08/02 09:00
CRDT- 2006/01/21 09:00
PHST- 2005/03/02 00:00 [received]
PHST- 2005/07/26 00:00 [accepted]
PHST- 2006/01/21 09:00 [pubmed]
PHST- 2006/08/02 09:00 [medline]
PHST- 2006/01/21 09:00 [entrez]
AID - S0021-9975(05)00094-0 [pii]
AID - 10.1016/j.jcpa.2005.07.004 [doi]
PST - ppublish
SO  - J Comp Pathol. 2006 Jan;134(1):111-4. doi: 10.1016/j.jcpa.2005.07.004.