PMID- 16423909
OWN - NLM
STAT- MEDLINE
DCOM- 20060413
LR  - 20220310
IS  - 0009-9147 (Print)
IS  - 0009-9147 (Linking)
VI  - 52
IP  - 3
DP  - 2006 Mar
TI  - Biological determinants of and reference values for plasma interleukin-8, 
      monocyte chemoattractant protein-1, epidermal growth factor, and vascular 
      endothelial growth factor: Results from the STANISLAS cohort.
PG  - 504-10
AB  - BACKGROUND: Interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), 
      epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) are 
      known to be involved in various diseases related to inflammation, vascular 
      remodeling, or growth deregulation. In addition, increases in plasma 
      concentrations of these cytokines appear to provide useful diagnostic and 
      prognostic information. We therefore investigated which factors most strongly 
      influence the biological variations of plasma IL-8, MCP-1, EGF, and VEGF 
      concentrations. METHODS: We used the Evidence biochip array analyzer to quantify 
      plasma IL-8, MCP-1, EGF, and VEGF concentrations in a subsample of 304 children 
      (age range, 4-17 years) and 540 adults (age range, 18-55 years) from the 
      STANISLAS family study. We also calculated reference intervals for the 4 
      cytokines. RESULTS: We found the following associations with plasma marker 
      concentrations: Age, neutrophil count, and glucose concentration were positively 
      associated with IL-8 concentrations in children and adults, as were smoking and 
      platelet count in adults. MCP-1 concentrations were associated with age and 
      smoking in both children and adults, monocyte count in children, and sex and 
      hematocrit in adults. EGF concentrations were associated with platelet count in 
      children and monocyte count and glucose in adults. VEGF concentrations were 
      associated with age in children and adults and platelet count and alanine 
      aminotransferase activity in adults. CONCLUSION: Our results for IL-8, MCP-1, 
      EGF, and VEGF may be useful for interpretation of patients' laboratory results 
      and for understanding the regulation of concentrations of these cytokines in 
      physiologic conditions.
FAU - Berrahmoune, Hind
AU  - Berrahmoune H
AD  - INSERM U525, Nancy, France.
FAU - Lamont, John V
AU  - Lamont JV
FAU - Herbeth, Bernard
AU  - Herbeth B
FAU - FitzGerald, Peter S
AU  - FitzGerald PS
FAU - Visvikis-Siest, Sophie
AU  - Visvikis-Siest S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060119
PL  - England
TA  - Clin Chem
JT  - Clinical chemistry
JID - 9421549
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Epidermal Growth Factor/*blood
MH  - Female
MH  - Humans
MH  - Interleukin-8/*blood
MH  - Male
MH  - Middle Aged
MH  - Plasma
MH  - Reference Values
MH  - Regression Analysis
MH  - Vascular Endothelial Growth Factor A/*blood
EDAT- 2006/01/21 09:00
MHDA- 2006/04/14 09:00
CRDT- 2006/01/21 09:00
PHST- 2006/01/21 09:00 [pubmed]
PHST- 2006/04/14 09:00 [medline]
PHST- 2006/01/21 09:00 [entrez]
AID - clinchem.2005.055798 [pii]
AID - 10.1373/clinchem.2005.055798 [doi]
PST - ppublish
SO  - Clin Chem. 2006 Mar;52(3):504-10. doi: 10.1373/clinchem.2005.055798. Epub 2006 
      Jan 19.