PMID- 16424389
OWN - NLM
STAT- MEDLINE
DCOM- 20060614
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 107
IP  - 10
DP  - 2006 May 15
TI  - Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the 
      germinal-center type B-cell lymphomas: a clinicopathologic analysis of cases 
      included in the German BFM (Berlin-Frankfurt-Munster) Multicenter Trial.
PG  - 4047-52
AB  - Diffuse large B-cell lymphoma (DLBCL) in adults is a heterogeneous disease. 
      Biologic subgroups of DLBCL with a favorable prognosis (germinal center 
      B-cell-like, GCB) and with a poor prognosis (activated B-cell-like, ABC) have 
      been defined by gene expression profiling and can be distinguished by 
      immunohistochemistry. In contrast to their adult counterparts, children with 
      DLBCL have an excellent prognosis. We analyzed 63 cases of DLBCL in pediatric 
      patients by immunohistochemistry and fluorescence in situ hybridization (FISH) 
      and found a striking predominance of a GCB subtype, which might explain the good 
      clinical outcome in these lymphomas. Interestingly, FISH applied to 50 of these 
      cases, as well as conventional cytogenetics available in 3 cases, revealed 
      absence of the translocation t(14;18) involving the BCL2 gene, which is present 
      in about 15% of adult GCB subtype DLBCL. Our data indicate that pediatric DLBCL 
      differs from adult DLBCL and might comprise a biologically unique subgroup of 
      DLBCL from which important insights into the pathogenesis and biology of this 
      disease might be gained.
FAU - Oschlies, Ilske
AU  - Oschlies I
AD  - Institute of Pathology, Department of Hematopathology and Lymph Node Registry 
      Kiel, Niemannsweg 11, 24105 Kiel, Germany.
FAU - Klapper, Wolfram
AU  - Klapper W
FAU - Zimmermann, Martin
AU  - Zimmermann M
FAU - Krams, Matthias
AU  - Krams M
FAU - Wacker, Hans-Heinrich
AU  - Wacker HH
FAU - Burkhardt, Birgit
AU  - Burkhardt B
FAU - Harder, Lana
AU  - Harder L
FAU - Siebert, Reiner
AU  - Siebert R
FAU - Reiter, Alfred
AU  - Reiter A
FAU - Parwaresch, Reza
AU  - Parwaresch R
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20060119
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 18
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Leukemia, Lymphoid/*classification/genetics/mortality/pathology
MH  - Lymphoma, B-Cell/*classification/genetics/mortality/pathology
MH  - Male
MH  - Survival Analysis
MH  - *Translocation, Genetic
EDAT- 2006/01/21 09:00
MHDA- 2006/06/15 09:00
CRDT- 2006/01/21 09:00
PHST- 2006/01/21 09:00 [pubmed]
PHST- 2006/06/15 09:00 [medline]
PHST- 2006/01/21 09:00 [entrez]
AID - S0006-4971(20)63835-6 [pii]
AID - 10.1182/blood-2005-10-4213 [doi]
PST - ppublish
SO  - Blood. 2006 May 15;107(10):4047-52. doi: 10.1182/blood-2005-10-4213. Epub 2006 
      Jan 19.