PMID- 1642585
OWN - NLM
STAT- MEDLINE
DCOM- 19920902
LR  - 20190718
IS  - 0004-8682 (Print)
IS  - 0004-8682 (Linking)
VI  - 62
IP  - 8
DP  - 1992 Aug
TI  - Photodynamic therapy in the treatment of subcutaneously implanted human bladder 
      tumour.
PG  - 643-9
AB  - Photodynamic therapy (PDT) is an experimental treatment modality for malignant 
      tumours. The effect of PDT with haematoporphyrin derivative (HpD) was studied 
      using a human bladder tumour (BL-17) which was implanted subcutaneously (s.c.) 
      into immunodeficient Balb/c nude mice. This model is only suitable for short-term 
      investigation of PDT because of the high mortality that arises due to the immune 
      deficiency of the animals. In a short-term observation (2 weeks post-treatment), 
      HpD sensitized PDT was effective in the control of tumour growth, with 71% of 
      tumours cured. The effect of PDT was found to be highly dependent on doses of HpD 
      and/or the activating laser light. The comparison of PDT effects of the gold 
      metal vapour laser (GMVL) and argon ion pumped dye laser (AIPDL) indicated that 
      no significant difference exists between these two different laser sources for 
      PDT. The irradiation with laser light alone and the administration of HpD alone 
      had no significant effect on tumour growth.
FAU - Han, W R
AU  - Han WR
AD  - Department of Surgery, Higginbotham Institute of Neurosurgery, University of 
      Melbourne, Royal Melbourne Hospital, Victoria, Australia.
FAU - Hill, J S
AU  - Hill JS
FAU - Stylli, S S
AU  - Stylli SS
FAU - Kaye, A H
AU  - Kaye AH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - Aust N Z J Surg
JT  - The Australian and New Zealand journal of surgery
JID - 0373115
SB  - IM
MH  - Animals
MH  - Carcinoma, Transitional Cell/*drug therapy/pathology
MH  - Cell Line
MH  - Disease Models, Animal
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Humans
MH  - Laser Therapy
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Neoplasm Transplantation
MH  - *Photochemotherapy/methods
MH  - Remission Induction
MH  - Urinary Bladder Neoplasms/*drug therapy/pathology
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
AID - 10.1111/j.1445-2197.1992.tb07537.x [doi]
PST - ppublish
SO  - Aust N Z J Surg. 1992 Aug;62(8):643-9. doi: 10.1111/j.1445-2197.1992.tb07537.x.