PMID- 16426240
OWN - NLM
STAT- MEDLINE
DCOM- 20060331
LR  - 20111117
IS  - 1744-3121 (Print)
IS  - 1744-3121 (Linking)
VI  - 33
IP  - 1
DP  - 2006 Feb
TI  - Characterization of a novel DRB1*14 allele (DRB1*1449) in the Han-Chinese 
      population.
PG  - 33-5
AB  - We report here a novel human leukocyte antigen (HLA) allele, DRB1*1449, in the 
      Han-Chinese population. The nature of the new allele was confirmed by the 
      sequencing-based typing (SBT) method. Genomic DNA and six subclones containing 
      DNA fragment of DRB1 exon 2 were sequenced in both forward and reverse 
      directions. The exon 2 nucleotide sequence of DRB1*1449 is closely related to 
      DRB1*1432 allele based on sequence homology. It has four nucleotide (nt) 
      substitutions at positions 71, 196, 244 and 245 in exon 2, which lead to changes 
      of amino acid sequences. The serological assignment of DRB1*1449 is DR14 based on 
      the serological HLA typing result. This novel allele might be a result of 
      recombination between DRB1*1402 and DRB1*140101 like alleles, which are very 
      common among Chinese population.
FAU - Miao, K R
AU  - Miao KR
AD  - The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 
      Province, PR China.
FAU - Xue, M
AU  - Xue M
FAU - Zhou, X Y
AU  - Zhou XY
FAU - Xu, R
AU  - Xu R
FAU - Fei, X M
AU  - Fei XM
FAU - Pan, Q Q
AU  - Pan QQ
FAU - Zhang, J W
AU  - Zhang JW
FAU - Zhao, X
AU  - Zhao X
FAU - Fan, S
AU  - Fan S
FAU - KuKuruga, D
AU  - KuKuruga D
FAU - Xu, A L
AU  - Xu AL
FAU - Wang, C Y
AU  - Wang CY
LA  - eng
SI  - GENBANK/AY912075
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Amino Acid Substitution
MH  - Base Sequence
MH  - China
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
EDAT- 2006/01/24 09:00
MHDA- 2006/04/01 09:00
CRDT- 2006/01/24 09:00
PHST- 2006/01/24 09:00 [pubmed]
PHST- 2006/04/01 09:00 [medline]
PHST- 2006/01/24 09:00 [entrez]
AID - EJI557 [pii]
AID - 10.1111/j.1744-313X.2005.00557.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2006 Feb;33(1):33-5. doi: 10.1111/j.1744-313X.2005.00557.x.