PMID- 16426712
OWN - NLM
STAT- MEDLINE
DCOM- 20061026
LR  - 20221207
IS  - 0264-410X (Print)
IS  - 0264-410X (Linking)
VI  - 24
IP  - 15
DP  - 2006 Apr 5
TI  - A pseudotype vesicular stomatitis virus containing Hantaan virus envelope 
      glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice.
PG  - 2928-34
AB  - We examined whether a vesicular stomatitis virus (VSV) pseudotype bearing the 
      hantavirus envelope glycoproteins (GPs) G1 and G2 (VSVdeltaG*HTN) could be used 
      as a safe and effective alternative to native hantavirus. Mice were immunized 
      with purified particles of VSVdeltaG*HTN. After the second immunization, all mice 
      produced anti-GP antibody as detected in ELISA and a neutralization test. After 
      the third immunization, the mice were challenged with Hantaan virus. Neither 
      anti-NP antibody production nor Hantaan virus-specific CD8 T-cell reactions were 
      detected in these mice. The present study demonstrated the potential of using a 
      pseudotype VSV system as a tool for developing a hantavirus vaccine.
FAU - Lee, Byoung-Hee
AU  - Lee BH
AD  - Institute for Animal Experimentation, Hokkaido University Graduate School of 
      Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan.
FAU - Yoshimatsu, Kumiko
AU  - Yoshimatsu K
FAU - Araki, Koichi
AU  - Araki K
FAU - Okumura, Megumi
AU  - Okumura M
FAU - Nakamura, Ichiro
AU  - Nakamura I
FAU - Arikawa, Jiro
AU  - Arikawa J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060106
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Synthetic)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (Viral Vaccines)
RN  - 0 (glycoprotein G1, Hantavirus)
RN  - 0 (glycoprotein G2, Hantavirus)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Orthohantavirus/genetics/*immunology
MH  - Hantavirus Infections/*prevention & control
MH  - Interferon-gamma/biosynthesis
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neutralization Tests
MH  - Vaccines, Synthetic/genetics/immunology
MH  - Vesicular stomatitis Indiana virus/genetics/*immunology
MH  - Viral Envelope Proteins/genetics/*immunology
MH  - Viral Vaccines/genetics/*immunology
EDAT- 2006/01/24 09:00
MHDA- 2006/10/27 09:00
CRDT- 2006/01/24 09:00
PHST- 2005/06/28 00:00 [received]
PHST- 2005/11/18 00:00 [revised]
PHST- 2005/12/14 00:00 [accepted]
PHST- 2006/01/24 09:00 [pubmed]
PHST- 2006/10/27 09:00 [medline]
PHST- 2006/01/24 09:00 [entrez]
AID - S0264-410X(05)01303-4 [pii]
AID - 10.1016/j.vaccine.2005.12.040 [doi]
PST - ppublish
SO  - Vaccine. 2006 Apr 5;24(15):2928-34. doi: 10.1016/j.vaccine.2005.12.040. Epub 2006 
      Jan 6.