PMID- 16427984
OWN - NLM
STAT- MEDLINE
DCOM- 20060307
LR  - 20220331
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 54
IP  - 2 Suppl
DP  - 2006 Feb
TI  - Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with 
      human herpesvirus 6 infection.
PG  - S14-7
AB  - Drug hypersensitivity syndrome (DHS) is an idiosyncratic and life-threatening 
      adverse drug reaction characterized by skin rash and multiorgan involvement. In 
      rare cases, fulminant type1 diabetes mellitus (DM) may develop after DHS. Among 
      proposed pathogenesis, human herpesvirus 6 (HHV-6) infections may play a role in 
      the development of DHS. We report a case of DHS associated with HHV-6 
      reactivation, complicated with a rare sequela of irreversible fulminant type 1 
      DM. No diabetes-related autoantibodies were detected. Early detection and 
      intervention for this serious complication should be given in patients with DHS. 
      Fulminant type1 DM associated with DHS is reviewed. The role of HHV-6 in DHS 
      associated with fulminant type 1 DM is also discussed.
FAU - Chiou, Chien-Chun
AU  - Chiou CC
AD  - Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
FAU - Chung, Wen-Hung
AU  - Chung WH
FAU - Hung, Shuen-Iu
AU  - Hung SI
FAU - Yang, Li-Cheng
AU  - Yang LC
FAU - Hong, Hong-Shang
AU  - Hong HS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 1/*etiology
MH  - Diabetic Ketoacidosis/etiology
MH  - Drug Eruptions/*complications/*virology
MH  - Herpesvirus 6, Human/*physiology
MH  - Humans
MH  - Male
MH  - Recurrence
MH  - Roseolovirus Infections/*complications
MH  - Virus Activation/*drug effects
RF  - 14
EDAT- 2006/01/24 09:00
MHDA- 2006/03/08 09:00
CRDT- 2006/01/24 09:00
PHST- 2004/12/21 00:00 [received]
PHST- 2005/03/21 00:00 [revised]
PHST- 2005/03/25 00:00 [accepted]
PHST- 2006/01/24 09:00 [pubmed]
PHST- 2006/03/08 09:00 [medline]
PHST- 2006/01/24 09:00 [entrez]
AID - S0190-9622(05)01037-6 [pii]
AID - 10.1016/j.jaad.2005.03.057 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2006 Feb;54(2 Suppl):S14-7. doi: 10.1016/j.jaad.2005.03.057.