PMID- 16430740
OWN - NLM
STAT- MEDLINE
DCOM- 20060518
LR  - 20131121
IS  - 0904-2512 (Print)
IS  - 0904-2512 (Linking)
VI  - 35
IP  - 2
DP  - 2006 Feb
TI  - The functional (-1171 5A-->6A) polymorphisms of matrix metalloproteinase 3 gene 
      as a risk factor for oral submucous fibrosis among male areca users.
PG  - 99-103
AB  - BACKGROUND: Insertion/deletion (-1171 5A-->6A) polymorphisms in the promoter 
      region of matrix metalloproteinase 3 (MMP3) gene result in different 
      transcriptional activities. MMP3 is able to degrade collagens types II, V, IX, 
      and X, and other extracellular matrix. The functional promoter polymorphism of 
      MMP3 has been related to the susceptibility in some inflammatory diseases and 
      metastasis of cancers. METHODS: Oral submucous fibrosis (OSF) and oral squamous 
      cell carcinoma (OSCC) are prevalent among Asian areca users. In this study, 
      genomic DNA obtained from the blood of OSCC (n = 150), OSF (n = 71), and control 
      non-diseased areca user (n = 98) in male were subjected to polymerase chain 
      reaction (PCR)-based genotyping of MMP3. RESULTS: The 5A genotype in MMP3 
      promoter was observed more frequently in OSF group than in control group (P = 
      0.01). No significant difference was noted between OSCC and control groups on the 
      5A genotype frequency (P = 0.18). No association was found between 5A genotype in 
      MMP3 promoter and site or lymph node metastasis and stage of OSCC. CONCLUSION: 
      The results indicated that the 5A genotype of MMP3 promoter was associated with 
      the risk of OSF but not OSCC.
FAU - Tu, H-F
AU  - Tu HF
AD  - Department of Dentistry, I-Lan Hospital, I-Lan, Taiwan.
FAU - Liu, C-J
AU  - Liu CJ
FAU - Chang, C-S
AU  - Chang CS
FAU - Lui, M-T
AU  - Lui MT
FAU - Kao, S-Y
AU  - Kao SY
FAU - Chang, C-P
AU  - Chang CP
FAU - Liu, T-Y
AU  - Liu TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 0 (DNA Transposable Elements)
RN  - 9007-49-2 (DNA)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - JAC85A2161 (Adenine)
SB  - IM
MH  - *Adenine
MH  - Adult
MH  - Areca/*adverse effects
MH  - Carcinoma, Squamous Cell/genetics
MH  - DNA/genetics
MH  - DNA Transposable Elements/*genetics
MH  - Disease Susceptibility
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Lymphatic Metastasis/genetics
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Mouth Neoplasms/genetics
MH  - Oral Submucous Fibrosis/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Promoter Regions, Genetic/genetics
MH  - Risk Factors
MH  - Sequence Deletion/*genetics
MH  - Transcription, Genetic/genetics
EDAT- 2006/01/25 09:00
MHDA- 2006/05/19 09:00
CRDT- 2006/01/25 09:00
PHST- 2006/01/25 09:00 [pubmed]
PHST- 2006/05/19 09:00 [medline]
PHST- 2006/01/25 09:00 [entrez]
AID - JOP370 [pii]
AID - 10.1111/j.1600-0714.2006.00370.x [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2006 Feb;35(2):99-103. doi: 10.1111/j.1600-0714.2006.00370.x.