PMID- 16433770
OWN - NLM
STAT- MEDLINE
DCOM- 20060217
LR  - 20230124
IS  - 1600-6135 (Print)
IS  - 1600-6135 (Linking)
VI  - 6
IP  - 1
DP  - 2006 Jan
TI  - Impaired left ventricular systolic function early after heart transplantation is 
      associated with cardiac allograft vasculopathy.
PG  - 161-8
AB  - Cardiac allograft vasculopathy (CAV) is a major cause of death more than 1 year 
      after heart transplantation. We evaluated the role and possible predictive value 
      of different etiological factors on development of CAV as diagnosed by 
      quantitative coronary angiography (QCA). A total of 121 patients were studied 
      with baseline QCA and 117 had a follow-up study at 1 year to assess the 
      relationship of mean lumen diameter loss (MLDL) in main coronary arteries to 
      immunological and non-immunological factors potentially affecting long-term 
      survival. Out of them, 103 patients were males (85%), 114 (94%) patients were 
      Caucasians and mean age was 48.5 +/- 10 years. Univariate analysis showed that 
      MLDL at 1 year was inversely related to echocardiographic fractional shortening 
      (FS) measured within the first week after transplantation (p = 0.0098) and to 
      intracranial hemorrhage as cause of donor death (p = 0.04) and was directly 
      related to male donors (p = 0.0008), domino transplants (p = 0.037) and donor 
      negative cytomegalovirus (CMV) status (p = 0.022). Multivariate analysis showed 
      that initial FS (p = 0.006) and donor intracranial hemorrhage as a cause of death 
      (p = 0.042) were inversely related to MLDL whereas donor male sex (p = 0.003) and 
      prednisolone treatment throughout the first year (p = 0.012) were directly 
      related. Thus, left ventricular systolic dysfunction early after heart 
      transplantation was associated with subsequent development of CAV.
FAU - Bolad, I A
AU  - Bolad IA
AD  - Transplant Unit, Harefield Hospital, Royal Brompton and Harefield NHS Trust, Hill 
      End Road, Harefield, Middlesex UB9 6JH, UK.
FAU - Robinson, D R
AU  - Robinson DR
FAU - Webb, C
AU  - Webb C
FAU - Hamour, I
AU  - Hamour I
FAU - Burke, M M
AU  - Burke MM
FAU - Banner, N R
AU  - Banner NR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Coronary Angiography/methods
MH  - Coronary Disease/diagnosis/diagnostic imaging/*etiology
MH  - Coronary Vessels/diagnostic imaging/pathology
MH  - Echocardiography
MH  - Female
MH  - *Heart Transplantation/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Systole
MH  - Transplantation, Homologous
MH  - Ventricular Dysfunction, Left/*complications/diagnosis/etiology
EDAT- 2006/01/26 09:00
MHDA- 2006/02/18 09:00
CRDT- 2006/01/26 09:00
PHST- 2006/01/26 09:00 [pubmed]
PHST- 2006/02/18 09:00 [medline]
PHST- 2006/01/26 09:00 [entrez]
AID - S1600-6135(22)02555-2 [pii]
AID - 10.1111/j.1600-6143.2005.01138.x [doi]
PST - ppublish
SO  - Am J Transplant. 2006 Jan;6(1):161-8. doi: 10.1111/j.1600-6143.2005.01138.x.