PMID- 16433829
OWN - NLM
STAT- MEDLINE
DCOM- 20060522
LR  - 20151119
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 55
IP  - 2
DP  - 2006 Feb
TI  - Killer immunoglobulin-like receptor and human leukocyte antigen expression as 
      immunodiagnostic parameters for pelvic endometriosis.
PG  - 106-14
AB  - PROBLEM: We investigated host immunologic responses to endometriosis by comparing 
      immune cell surface antigens in peripheral blood (PB) and peritoneal fluid (PF) 
      from women with endometriosis with those in PB and PF from other patients. METHOD 
      OF STUDY: Japanese women with endometriosis (n = 56) were compared with controls 
      with other laparoscopic diagnoses (n = 68). PB and PF were collected at the time 
      of laparoscopy for flow cytometry. RESULTS: No significant difference in 
      phenotypic parameters of T cells (CD3, CD4, and CD8), B cells (CD19), natural 
      killer (NK) cells (CD56), or monocytes/macrophages (CD14) was seen between women 
      with and without endometriosis. However, increased killer immunoglobulin-like 
      receptor (CD158a) expression by NK cells and decreased human leukocyte antigen 
      (HLA)-ABC and -DR expression by macrophages, all suggesting decreased functional 
      activation were found in endometriosis. These markers showed significant 
      association with endometriosis by odds ratio, logistic regression, and decision 
      tree analyses. CONCLUSIONS: Increased CD158a(+) NK cells in PB and PF indicated 
      decreased NK cell cytotoxicity in endometriosis, while decreased HLA expression 
      on PF macrophages suggested impaired antigen presentation. Thus, aberrant immune 
      responses by NK cells and macrophages may represent risk factors for 
      endometriosis.
FAU - Zhang, Chunbin
AU  - Zhang C
AD  - Department of Biology, Jiamusi University, HeiLong Jiang, China.
FAU - Maeda, Nagamasa
AU  - Maeda N
FAU - Izumiya, Chiaki
AU  - Izumiya C
FAU - Yamamoto, Yorito
AU  - Yamamoto Y
FAU - Kusume, Tomoaki
AU  - Kusume T
FAU - Oguri, Hiroyoshi
AU  - Oguri H
FAU - Yamashita, Chika
AU  - Yamashita C
FAU - Nishimori, Yoshiko
AU  - Nishimori Y
FAU - Hayashi, Kazutoshi
AU  - Hayashi K
FAU - Luo, Jiabin
AU  - Luo J
FAU - Fukaya, Takao
AU  - Fukaya T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL1)
SB  - IM
MH  - Biomarkers
MH  - Case-Control Studies
MH  - Disease Susceptibility
MH  - Endometriosis/*diagnosis
MH  - Female
MH  - HLA Antigens/*metabolism
MH  - Humans
MH  - Leukocytes/*metabolism
MH  - *Pelvis
MH  - Receptors, Immunologic/*metabolism
MH  - Receptors, KIR
MH  - Receptors, KIR2DL1
EDAT- 2006/01/26 09:00
MHDA- 2006/05/23 09:00
CRDT- 2006/01/26 09:00
PHST- 2006/01/26 09:00 [pubmed]
PHST- 2006/05/23 09:00 [medline]
PHST- 2006/01/26 09:00 [entrez]
AID - AJI332 [pii]
AID - 10.1111/j.1600-0897.2005.00332.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2006 Feb;55(2):106-14. doi: 
      10.1111/j.1600-0897.2005.00332.x.