PMID- 16434317
OWN - NLM
STAT- MEDLINE
DCOM- 20060310
LR  - 20091119
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 164
IP  - 2
DP  - 2006 Jan 15
TI  - Complex rearrangements involving der(8)t(8;20) and der(14)t(8;14)t(11;14), CCND1, 
      and duplication of IgH constant region in acute plasmablastic leukemia.
PG  - 137-41
AB  - We report on a rapidly fatal case of acute plasmablastic leukemia in a 
      72-year-old male from The Ukraine, who was 70 km away from Chernobyl at the time 
      of the atomic accident in 1986. Spectral karyotyping and fluorescence in situ 
      hybridization (FISH) studies of a bone marrow sample obtained at diagnosis 
      revealed a hypodiploid karyotype with 45 chromosomes and two novel complex 
      rearrangements, der(8)t(8;20)(p11.2;p?12) and 
      der(14)t(8;14)(p?;p11.2)t(11;14)(q13;q32), with juxtaposition of CH (constant 
      region of IgH) sequences to the oncogene CCND1 (translocated to 14q32). FISH 
      analysis demonstrated that the CH on the der(14) was duplicated.
FAU - Knutsen, Turid
AU  - Knutsen T
AD  - Genetics Branch, Center for Clinical Research, National Cancer Institute, 50 
      South Drive, Room 1408, Bethesda, MD 20892-8010, USA. knutsent@mail.nih.gov
FAU - Vakulchuk, Alexander
AU  - Vakulchuk A
FAU - Mosijczuk, Askold D
AU  - Mosijczuk AD
FAU - Gabrea, Ana
AU  - Gabrea A
FAU - Ried, Thomas
AU  - Ried T
FAU - Tretyak, Natalia
AU  - Tretyak N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (CCND2 protein, human)
RN  - 0 (Cyclin D2)
RN  - 0 (Cyclins)
RN  - 0 (Immunoglobulin Heavy Chains)
SB  - IM
MH  - Aged
MH  - Chernobyl Nuclear Accident
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human
MH  - Cyclin D2
MH  - Cyclins/*genetics
MH  - Gene Duplication
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunoglobulin Heavy Chains/*genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Plasma Cell/*drug therapy/*genetics/pathology
MH  - Male
MH  - Spectral Karyotyping
MH  - Translocation, Genetic
EDAT- 2006/01/26 09:00
MHDA- 2006/03/11 09:00
CRDT- 2006/01/26 09:00
PHST- 2005/06/20 00:00 [received]
PHST- 2005/08/19 00:00 [revised]
PHST- 2005/08/22 00:00 [accepted]
PHST- 2006/01/26 09:00 [pubmed]
PHST- 2006/03/11 09:00 [medline]
PHST- 2006/01/26 09:00 [entrez]
AID - S0165-4608(05)00504-2 [pii]
AID - 10.1016/j.cancergencyto.2005.08.027 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2006 Jan 15;164(2):137-41. doi: 
      10.1016/j.cancergencyto.2005.08.027.