PMID- 16435253
OWN - NLM
STAT- MEDLINE
DCOM- 20060314
LR  - 20191210
IS  - 1438-9029 (Print)
IS  - 1438-9010 (Linking)
VI  - 178
IP  - 2
DP  - 2006 Feb
TI  - [Intravascular optical coherence tomography: differentiation of atherosclerotic 
      plaques and quantification of vessel dimensions in crural arterial specimens].
PG  - 214-20
AB  - PURPOSE: Intravascular optical coherence tomography (OCT) is a new technique 
      based on infrared light that visualizes the arteries with a resolution of 10-20 
      microm. Intravascular ultrasound (IVUS) is the current in vivo reference standard 
      and provides a resolution of 100-150 microm. This study compared OCT to IVUS and 
      histopathology with respect to the ability to differentiate atherosclerotic 
      plaques and quantify vascular dimensions in peripheral crural arteries ex vivo. 
      MATERIALS AND METHODS: 50 segments of atherosclerotic arteries derived from five 
      amputated human lower extremities were examined. The different plaque types 
      (fibrous, high-lipid content, calcified) were assigned by two independent 
      examiners, and the sensitivity and specificity of OCT in comparison with 
      histopathology as well as intra- and interobserver consensus were calculated. A 
      comparison of OCT with IVUS addressed the parameters: luminal area (LA), vascular 
      wall area (VA) and plaque area (PA). RESULTS: When comparing OCT and 
      histopathology with respect to the differentiation of various plaque types, 
      sensitivities of 81 % and specificities of 89 % for fibrous plaques, of 100 % and 
      93 % for lipid-rich plaques and of 80 % and 89 % for calcified plaques were 
      achieved (overall correlation 83 %). Intra- and interobserver consensus was very 
      high (kappa = 0.86 and kappa = 0.89, p < 0.001, respectively). There was also a 
      high correlation between quantitative measurements (Bland-Altman plot [LA]: mean 
      bias, 0.1 mm(2) accuracy +/- 1.8 mm(2), r = 0.95 [p < 0.001] Bland-Altman plot 
      [VA]: mean bias, 0.3 mm(2) accuracy +/- 2.3 mm(2), r = 0.94 [p < 0.001] 
      Bland-Altman plot [PA]: mean bias, 0.4 mm(2) accuracy +/- 2.3 mm(2), r = 0.80 [p 
      < 0.01]. CONCLUSION: OCT allows the differentiation of atherosclerotic plaque 
      types in crural arteries with high accuracy compared to histopathology. 
      Quantitative measurements show a high correlation with IVUS, the current 
      reference standard.
FAU - Meissner, O A
AU  - Meissner OA
AD  - Institut fur Klinische Radiologie, Ludwig-Maximilians-Universitat Munchen. 
      oliver.meissner@med.uni-muenchen.de
FAU - Rieber, J
AU  - Rieber J
FAU - Babaryka, G
AU  - Babaryka G
FAU - Oswald, M
AU  - Oswald M
FAU - Reim, S
AU  - Reim S
FAU - Siebert, U
AU  - Siebert U
FAU - Redel, T
AU  - Redel T
FAU - Eibel, R
AU  - Eibel R
FAU - Mueller-Lisse, U
AU  - Mueller-Lisse U
FAU - Reiser, M
AU  - Reiser M
FAU - Mueller-Lisse, U G
AU  - Mueller-Lisse UG
LA  - ger
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Intravaskulare optische Koharenztomographie: Unterscheidung verschiedener 
      Plaquetypen und Vermessung von Gefassdimensionen in atherosklerotischen 
      Unterschenkelarterien.
PL  - Germany
TA  - Rofo
JT  - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
JID - 7507497
SB  - IM
MH  - Atherosclerosis/*classification/*pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - In Vitro Techniques
MH  - Leg/blood supply/pathology
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
EDAT- 2006/01/26 09:00
MHDA- 2006/03/15 09:00
CRDT- 2006/01/26 09:00
PHST- 2006/01/26 09:00 [pubmed]
PHST- 2006/03/15 09:00 [medline]
PHST- 2006/01/26 09:00 [entrez]
AID - 10.1055/s-2005-858922 [doi]
PST - ppublish
SO  - Rofo. 2006 Feb;178(2):214-20. doi: 10.1055/s-2005-858922.