PMID- 16436144
OWN - NLM
STAT- MEDLINE
DCOM- 20060707
LR  - 20061115
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 61
IP  - 3
DP  - 2006 Mar
TI  - Screening for allergic respiratory disease in the general population with the 
      ADVIA Centaur Allergy Screen Assay.
PG  - 344-8
AB  - BACKGROUND: In patients in whom the clinical indication for immunoglobulin E 
      (IgE)-mediated allergic respiratory disease is weak, a single qualitative 
      multiallergen-screening assay for IgE antibody to multiple allergen specificities 
      may support the absence of IgE-mediated allergic respiratory disease. The aim was 
      to investigate the diagnostic efficacy of a new multiallergen-screening assay in 
      relation to skin prick test (SPT) reactivity and objective diagnoses of allergic 
      respiratory disease in a general population setting. METHODS: A total of 709 
      participants in a population-based study were examined by questionnaire and SPT. 
      Serum was analysed by using a multiallergen-screening assay: the ADVIA Centaur 
      Allergy Screen (AS) assay. The dichotomized result of the AS assay was compared 
      with SPT reactivity, specific IgE positivity, and a clinical diagnosis of 
      allergic rhinitis or allergic asthma defined by the presence of relevant symptoms 
      and positive SPTs. RESULTS: Sensitivity, specificity, and positive (PPV) and 
      negative predictive values (NPV) of the AS against SPT reactivity were 86%, 96%, 
      94%, and 89%, respectively. A negative AS assay test was able to exclude allergic 
      rhinitis and allergic asthma with a probability of more than 96% and 98% (NPV), 
      respectively. The AS assay was able to identify more than 92% and 92% 
      (sensitivity) of cases of allergic rhinitis and allergic asthma, respectively. 
      CONCLUSIONS: The AS assay proved to be a valid measure of allergic respiratory 
      disease and may be used as a screening tool to rule out allergic respiratory 
      disease, and as an objective measure of allergic respiratory disease in 
      epidemiological studies.
FAU - Linneberg, A
AU  - Linneberg A
AD  - Research Centre for Prevention and Health, Glostrup University Hospital, 
      Glostrup, Denmark.
FAU - Husemoen, L L N
AU  - Husemoen LL
FAU - Nielsen, N H
AU  - Nielsen NH
FAU - Madsen, F
AU  - Madsen F
FAU - Frolund, L
AU  - Frolund L
FAU - Johansen, N
AU  - Johansen N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibodies, Anti-Idiotypic/*blood
MH  - Asthma/diagnosis/epidemiology
MH  - Cohort Studies
MH  - Confidence Intervals
MH  - Desensitization, Immunologic
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*diagnosis/epidemiology
MH  - Immunoglobulin E/*immunology
MH  - Immunologic Tests/methods
MH  - Male
MH  - Mass Screening/*methods
MH  - Prevalence
MH  - Probability
MH  - Prospective Studies
MH  - Respiratory Hypersensitivity/*diagnosis/epidemiology
MH  - Rhinitis, Allergic, Seasonal/diagnosis/epidemiology
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Skin Tests/methods
EDAT- 2006/01/27 09:00
MHDA- 2006/07/11 09:00
CRDT- 2006/01/27 09:00
PHST- 2006/01/27 09:00 [pubmed]
PHST- 2006/07/11 09:00 [medline]
PHST- 2006/01/27 09:00 [entrez]
AID - ALL968 [pii]
AID - 10.1111/j.1398-9995.2006.00968.x [doi]
PST - ppublish
SO  - Allergy. 2006 Mar;61(3):344-8. doi: 10.1111/j.1398-9995.2006.00968.x.