PMID- 16436209
OWN - NLM
STAT- MEDLINE
DCOM- 20060323
LR  - 20220330
IS  - 1477-7827 (Electronic)
IS  - 1477-7827 (Linking)
VI  - 4
DP  - 2006 Jan 25
TI  - Is there a relationship between sperm chromosome abnormalities and sperm 
      morphology?
PG  - 1
AB  - This review explores the relationship between sperm chromosomal constitution and 
      morphology. With the advent of techniques for obtaining information on the 
      chromosome complements of spermatozoa, this relationship has been studied in 
      fertile men and in men with a high frequency of chromosomal abnormalities. Using 
      human sperm karyotype analysis, no relationship between sperm chromosome 
      abnormalities and morphology was found in fertile men, translocation carriers or 
      post-radiotherapy cancer patients. Fluorescence in situ hybridization (FISH) 
      analysis has not generally revealed a specific association between 
      morphologically abnormal sperm and sperm chromosome abnormalities, but has 
      indicated that teratozoospermia, like other forms of abnormal semen profiles 
      (aesthenozoospermia, oligozoospermia) is associated with a modest increase in the 
      frequency of sperm chromosome abnormalities. However, FISH studies on some 
      infertile men and mouse strains have suggested that certain types of 
      morphologically abnormal spermatozoa, such as macrocephalic multitailed 
      spermatozoa, are associated with a very significantly increased frequency of 
      aneuploidy. Thus, there may be an association between sperm morphology and 
      aneuploidy in infertile men with specific abnormalities.
FAU - Sun, Fei
AU  - Sun F
AD  - Department of Medical Genetics, Faculty of Medicine, University of Calgary, 
      Calgary, Alberta T2N 4N1, Canada. fesun@ucalgary.ca
FAU - Ko, Evelyn
AU  - Ko E
FAU - Martin, Renee H
AU  - Martin RH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060125
PL  - England
TA  - Reprod Biol Endocrinol
JT  - Reproductive biology and endocrinology : RB&E
JID - 101153627
SB  - IM
MH  - Adult
MH  - Animals
MH  - *Chromosome Aberrations
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/genetics/pathology
MH  - Karyotyping
MH  - Male
MH  - Mice
MH  - Middle Aged
MH  - Oligospermia/genetics/pathology
MH  - Spermatozoa/*abnormalities/pathology
PMC - PMC1395314
EDAT- 2006/01/27 09:00
MHDA- 2006/03/24 09:00
PMCR- 2006/01/25
CRDT- 2006/01/27 09:00
PHST- 2006/01/20 00:00 [received]
PHST- 2006/01/25 00:00 [accepted]
PHST- 2006/01/27 09:00 [pubmed]
PHST- 2006/03/24 09:00 [medline]
PHST- 2006/01/27 09:00 [entrez]
PHST- 2006/01/25 00:00 [pmc-release]
AID - 1477-7827-4-1 [pii]
AID - 10.1186/1477-7827-4-1 [doi]
PST - epublish
SO  - Reprod Biol Endocrinol. 2006 Jan 25;4:1. doi: 10.1186/1477-7827-4-1.