PMID- 1643671
OWN - NLM
STAT- MEDLINE
DCOM- 19920909
LR  - 20190824
IS  - 0009-2797 (Print)
IS  - 0009-2797 (Linking)
VI  - 83
IP  - 1
DP  - 1992 Jun 15
TI  - Antioxidant activity of the pyridoindole stobadine in liposomal and microsomal 
      lipid peroxidation.
PG  - 85-93
AB  - Stobadine, a pyridoindole derivative, is an efficient inhibitor of lipid 
      peroxidation in phosphatidylcholine liposomes and in rat liver microsomes treated 
      with iron/ADP/NADPH as pro-oxidant. Accumulation of thiobarbituric acid-reactive 
      substances (TBARS) or low-level chemiluminescence were taken as a measure of 
      lipid peroxidation and 5 microM stobadine doubled the duration of the lag phase 
      preceding the onset of rapidly increasing chemiluminescence. Inhibition of lipid 
      peroxidation was not observed with tocopherol-deficient microsomes, suggesting 
      that the antioxidant effect of stobadine depends on vitamin E in the membrane. 
      The cis(-) isomer was most effective, with the cis(+) and trans(rac) as well as 
      dehydro- or acetyl derivatives being less active. In liposomes, the presence of 
      reductant (NADPH or ascorbate) protects from the loss of stobadine.
FAU - Horakova, L
AU  - Horakova L
AD  - Institut fur Physiologische Chemie I, Universitat Dusseldorf, Germany.
FAU - Briviba, K
AU  - Briviba K
FAU - Sies, H
AU  - Sies H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Antioxidants)
RN  - 0 (Carbolines)
RN  - 0 (Indoles)
RN  - 0 (Liposomes)
RN  - 0 (Phosphatidylcholines)
RN  - 0 (Sulfhydryl Compounds)
RN  - 0 (Thiobarbiturates)
RN  - 1406-18-4 (Vitamin E)
RN  - 53-59-8 (NADP)
RN  - 61D2G4IYVH (Adenosine Diphosphate)
RN  - E1UOL152H7 (Iron)
RN  - PQ6CK8PD0R (Ascorbic Acid)
RN  - Y0EA50IJ3V (dicarbine)
SB  - IM
MH  - Adenosine Diphosphate/pharmacology
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Ascorbic Acid/pharmacology
MH  - Carbolines/*pharmacology
MH  - Chromatography, High Pressure Liquid
MH  - Indoles/*pharmacology
MH  - Iron/pharmacology
MH  - Lipid Peroxidation/*drug effects
MH  - Liposomes/*metabolism
MH  - Microsomes, Liver/drug effects/*metabolism
MH  - NADP/pharmacology
MH  - Phosphatidylcholines/metabolism
MH  - Rats
MH  - Stereoisomerism
MH  - Sulfhydryl Compounds/metabolism
MH  - Thiobarbiturates/pharmacokinetics
MH  - Vitamin E/metabolism
EDAT- 1992/06/15 00:00
MHDA- 1992/06/15 00:01
CRDT- 1992/06/15 00:00
PHST- 1992/06/15 00:00 [pubmed]
PHST- 1992/06/15 00:01 [medline]
PHST- 1992/06/15 00:00 [entrez]
AID - 0009-2797(92)90094-2 [pii]
AID - 10.1016/0009-2797(92)90094-2 [doi]
PST - ppublish
SO  - Chem Biol Interact. 1992 Jun 15;83(1):85-93. doi: 10.1016/0009-2797(92)90094-2.