PMID- 16437632
OWN - NLM
STAT- MEDLINE
DCOM- 20060320
LR  - 20190430
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 11
IP  - 46
DP  - 2005 Dec 14
TI  - Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous 
      clearance of hepatitis C virus infection: a meta-analysis.
PG  - 7302-7
AB  - AIM: To assess the associations of human leukocyte antigen (HLA) class II 
      DQB1*0301 and/or DRB1*1101 allele with spontaneous hepatitis C virus (HCV) 
      clearance by meta-analysis of individual dataset from all studies published till 
      date. METHODS: To clarify the impact of HLA class II polymorphisms on viral 
      clearance, we performed a meta-analysis of the published data from 11 studies 
      comparing the frequencies of DQB1*0301 and DRB1*1101 alleles in individuals with 
      spontaneous resolution to those with persistent infection. As we identified the 
      heterogeneity between studies, summary statistical data were calculated based on 
      a random-effect model. RESULTS: Meta-analyses yielded summary estimates-odds 
      ratio (OR) of 2.36 [95%CI (1.62, 3.43), P<0.00001] and 2.02 [95%CI (1.56, 2.62), 
      P<0.00001] for the effects of DQB1*0301 and DRB1*1101 alleles on spontaneous 
      clearance of HCV, respectively. CONCLUSION: These results support the hypothesis 
      that specific HLA class II alleles might influence the susceptibility or 
      resistance to persistent HCV infection. Both DQB1*0301 and DRB1*1101 are 
      protective alleles and present HCV epitopes more effectively to CD4(+)T 
      lymphocytes than others, and subjects with these two alleles are at a lower risk 
      of developing chronic HCV infection. Large, multi-ethnic confirmatory and 
      well-designed studies are needed to determine the host genetic determinants of 
      HCV infection.
FAU - Hong, Xin
AU  - Hong X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing 
      Medical University, Nanjing 210029, Jiangsu Province, China.
FAU - Yu, Rong-Bin
AU  - Yu RB
FAU - Sun, Nan-Xiong
AU  - Sun NX
FAU - Wang, Bin
AU  - Wang B
FAU - Xu, Yao-Chu
AU  - Xu YC
FAU - Wu, Guan-Ling
AU  - Wu GL
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Hepacivirus/isolation & purification
MH  - Hepatitis C/*genetics/*immunology/virology
MH  - Humans
MH  - Polymorphism, Genetic
PMC - PMC4725151
EDAT- 2006/01/27 09:00
MHDA- 2006/03/21 09:00
PMCR- 2005/12/14
CRDT- 2006/01/27 09:00
PHST- 2006/01/27 09:00 [pubmed]
PHST- 2006/03/21 09:00 [medline]
PHST- 2006/01/27 09:00 [entrez]
PHST- 2005/12/14 00:00 [pmc-release]
AID - 10.3748/wjg.v11.i46.7302 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2005 Dec 14;11(46):7302-7. doi: 10.3748/wjg.v11.i46.7302.