PMID- 16438294
OWN - NLM
STAT- MEDLINE
DCOM- 20060227
LR  - 20161124
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 561
DP  - 2005
TI  - Kinetic and mechanistic data needs for a human phsiologically based 
      pharmacokinetic (PBPK) model for acrylamide: pharmacokinetic model for 
      acrylamide.
PG  - 117-25
AB  - A pharmacokinetic (PBPK) model has been developed for acrylamide (AMD) and its 
      oxidative metabolite, glycidamide (GLY), in the rat based on available 
      information. Despite gaps and limitations to the database, model parameters have 
      been estimated to provide a relatively consistent description of the kinetics of 
      acrylamide and glycidamide using a single set of values (with minor adjustments 
      in some cases). Future kinetic and mechanistic studies will need to focus on the 
      collection of key data for refining certain model parameters and for model 
      validation, as well as for conducting studies that elucidate the mechanism of 
      action. Development of a validated human AMD/GLY PBPK model capable of predicting 
      target tissue doses at relevant dietary AMD exposures, in combination with 
      expanding data on modes of action, should allow for a substantive improvement in 
      the risk assessment of acrylamide in food.
FAU - Andersen, Melvin E
AU  - Andersen ME
AD  - CllT Centers for Health Research, Six Davis Drive, PO Box 12137, Research 
      Triangle Park, NC 27709-2137, USA. MAndersen@ciit.org
FAU - Scimeca, Joseph
AU  - Scimeca J
FAU - Olin, Stephen S
AU  - Olin SS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (DNA Adducts)
RN  - 0 (Epoxy Compounds)
RN  - 20R035KLCI (Acrylamide)
RN  - 6G5ELX5XYN (glycidamide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Acrylamide/*pharmacokinetics/*toxicity
MH  - Animals
MH  - Area Under Curve
MH  - DNA Adducts
MH  - Epoxy Compounds/chemistry/*pharmacokinetics
MH  - Humans
MH  - Kinetics
MH  - Models, Chemical
MH  - Models, Statistical
MH  - Oxygen/chemistry
MH  - Rats
MH  - Research Design
MH  - Risk Assessment/*methods
MH  - Tissue Distribution
RF  - 12
EDAT- 2006/01/28 09:00
MHDA- 2006/02/28 09:00
CRDT- 2006/01/28 09:00
PHST- 2006/01/28 09:00 [pubmed]
PHST- 2006/02/28 09:00 [medline]
PHST- 2006/01/28 09:00 [entrez]
AID - 10.1007/0-387-24980-X_10 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2005;561:117-25. doi: 10.1007/0-387-24980-X_10.