PMID- 16438618
OWN - NLM
STAT- MEDLINE
DCOM- 20060725
LR  - 20061115
IS  - 0031-8655 (Print)
IS  - 0031-8655 (Linking)
VI  - 82
IP  - 3
DP  - 2006 May-Jun
TI  - Photostability of bacteriochlorophyll a and derivatives: potential sensitizers 
      for photodynamic tumor therapy.
PG  - 770-80
AB  - The photostabilities of bacteriochlorophyll a and several of its derivatives, 
      which are of interest as potential sensitizers in photodynamic tumor therapy, 
      were investigated. The pigments were irradiated with light >630 nm in organic 
      solvents (acetone, tetrahydrofuran, pyridine, methanol, ethanol, n-propanol, 
      2-propanol and toluene) and in aqueous detergent solutions 
      (cetyl-trimethyl-ammonium bromide [CTAB], lauryldimethyl-aminoxide [LDAO] or 
      sodium dodecyl-sulfate [SDS] and Triton X-100 [TX100]). Their stabilities in 
      these different solvents were determined in the presence and absence of an 
      external sensitizer (pyromethyl-pheophorbide a), oxygen, sodium ascorbate and 
      inert gas (Ar) or vacuum. The photodegradation products of bacteriochlorophyll a 
      in acetone solution were isolated, purified by HPLC and analyzed by their 
      absorption spectra and mass spectroscopy. Besides the well-known dehydrogenation 
      products, such as [3-acetyl]-chlorophyll a, which were obtained as by-products, 
      the major products had low absorption in the visible-near infrared spectral 
      range. The spectral signature of the major component of these products was 
      characteristic of linear open-chain tetrapyrroles, but they lacked the 
      characteristic protonation-deprotonation behavior and reactivity of bilins with 
      Zn(++).
FAU - Limantara, Leenawaty
AU  - Limantara L
AD  - Department Biologie I, Bereich Botanik, Ludwig Maximilians Universitat Munchen, 
      Germany.
FAU - Koehler, Peter
AU  - Koehler P
FAU - Wilhelm, Brigitte
AU  - Wilhelm B
FAU - Porra, Robert J
AU  - Porra RJ
FAU - Scheer, Hugo
AU  - Scheer H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Photochem Photobiol
JT  - Photochemistry and photobiology
JID - 0376425
RN  - 0 (Bacteriochlorophylls)
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Bacteriochlorophylls/*radiation effects
MH  - *Light
MH  - Neoplasms/therapy
MH  - Photochemistry
MH  - Photochemotherapy/methods
MH  - Photosensitizing Agents/*chemistry/radiation effects
EDAT- 2006/01/28 09:00
MHDA- 2006/07/26 09:00
CRDT- 2006/01/28 09:00
PHST- 2006/01/28 09:00 [pubmed]
PHST- 2006/07/26 09:00 [medline]
PHST- 2006/01/28 09:00 [entrez]
AID - 2005-09-07-RA-676 [pii]
AID - 10.1562/2005-09-07-RA-676 [doi]
PST - ppublish
SO  - Photochem Photobiol. 2006 May-Jun;82(3):770-80. doi: 10.1562/2005-09-07-RA-676.