PMID- 16438671
OWN - NLM
STAT- MEDLINE
DCOM- 20060302
LR  - 20081121
IS  - 0141-9838 (Print)
IS  - 0141-9838 (Linking)
VI  - 28
IP  - 1-2
DP  - 2006 Jan-Feb
TI  - Antigen presentation and dendritic cell biology in malaria.
PG  - 5-14
AB  - Dendritic cells (DCs) are important both in amplifying the innate immune response 
      and in initiating adaptive immunity and shaping the type of T helper (Th) 
      response. Although the role of DCs in immune responses to many intracellular 
      pathogens has been delineated and research is underway to identify the mechanisms 
      involved, relatively little is known concerning the role of DCs in immunity to 
      malaria. In this review, we provide an overview and summary of previous and 
      current studies aimed to investigate the role of DCs as antigen presenting cells 
      (APCs). In addition, the role of DCs in inducing innate and adaptive immunity to 
      blood-stage malaria is discussed and, where information is available, the 
      mechanisms involved are presented. Data from studies in humans infected with 
      Plasmodium falciparum, the major human parasite responsible for the high 
      morbidity and mortality associated with malaria throughout many regions of the 
      developing world, as well as data from experimental mouse models are presented. 
      Overall, the data from these studies are conflicting. The possible reasons for 
      these differences, including the use of different parasite species and parasite 
      strains in the mouse studies, are discussed. Nevertheless, together the data have 
      important implications for development of an effective malaria vaccine since the 
      selection of appropriate Plasmodium antigens and/or adjuvants, targeting innate 
      immune responses involving DCs, may provide optimal protection against malaria. 
      It is hoped that this review promotes more investigation among malariologists and 
      immunologists alike on DCs and malaria.
FAU - Stevenson, M M
AU  - Stevenson MM
AD  - Research Institute of the McGill University Health Centre, Montreal, Quebec, 
      Canada. mary.m.stevenson@mcgill.ca
FAU - Urban, B C
AU  - Urban BC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Parasite Immunol
JT  - Parasite immunology
JID - 7910948
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Dendritic Cells/cytology/*immunology/parasitology
MH  - Erythrocytes/immunology/parasitology
MH  - Humans
MH  - Immunity, Innate/immunology
MH  - Malaria/*immunology/parasitology
MH  - Malaria, Falciparum/immunology/parasitology
MH  - Mice
MH  - Plasmodium chabaudi/*immunology
MH  - Plasmodium falciparum/*immunology
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
MH  - Toll-Like Receptors/immunology
RF  - 63
EDAT- 2006/01/28 09:00
MHDA- 2006/03/03 09:00
CRDT- 2006/01/28 09:00
PHST- 2006/01/28 09:00 [pubmed]
PHST- 2006/03/03 09:00 [medline]
PHST- 2006/01/28 09:00 [entrez]
AID - PIM772 [pii]
AID - 10.1111/j.1365-3024.2006.00772.x [doi]
PST - ppublish
SO  - Parasite Immunol. 2006 Jan-Feb;28(1-2):5-14. doi: 
      10.1111/j.1365-3024.2006.00772.x.