PMID- 16439097
OWN - NLM
STAT- MEDLINE
DCOM- 20060925
LR  - 20131121
IS  - 0890-6238 (Print)
IS  - 0890-6238 (Linking)
VI  - 22
IP  - 1
DP  - 2006 Jul
TI  - The maternal combined supplementation of folic acid and Vitamin B(12) suppresses 
      ethanol-induced developmental toxicity in mouse fetuses.
PG  - 56-61
AB  - Maternal ethanol consumption during pregnancy can induce developmental defects in 
      the fetus. The objective of this study was to assess whether combined 
      supplementation of folic acid (FA) and Vitamin B(12) (VB(12)) in dams would 
      suppress ethanol-induced developmental toxicity in CD-1 mice. Ethanol (5.0 g/kg) 
      was given intragastrically from gestational day (GD) 6 to GD15. Vitamin 
      supplementation groups were additionally given 60.0 mg/kg FA, 1.0 mg/kg VB(12), 
      or 60.0 mg/kg FA+1.0 mg/kg VB(12) during GD1-16. The control group received 
      distilled water only. Results of litter evaluation on GD18 showed that combined 
      supplementation of FA and VB(12) ameliorated many of the adverse effects of 
      ethanol. In contrast, the single vitamin supplementation groups showed little or 
      no amelioration. These results suggest that combined supplementation of FA and 
      VB(12) was more effective than each vitamin toward suppressing ethanol-induced 
      developmental toxicity in CD-1 mice.
FAU - Xu, Yajun
AU  - Xu Y
AD  - Department of Nutrition and Food Hygiene, Laboratory of Molecular Toxicology and 
      Developmental Molecular Biology, School of Public Health, Peking University, 
      Beijing 100083, China.
FAU - Li, Yong
AU  - Li Y
FAU - Tang, Yunan
AU  - Tang Y
FAU - Wang, Junbo
AU  - Wang J
FAU - Shen, Xiaoyi
AU  - Shen X
FAU - Long, Zhu
AU  - Long Z
FAU - Zheng, Xiaoying
AU  - Zheng X
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060124
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 3K9958V90M (Ethanol)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Abnormalities, Drug-Induced/etiology/prevention & control
MH  - Alcoholic Intoxication/etiology/prevention & control
MH  - Animals
MH  - Bone and Bones/abnormalities/drug effects/embryology
MH  - *Dietary Supplements
MH  - Embryo Implantation/drug effects
MH  - Embryo Loss/chemically induced/prevention & control
MH  - Ethanol/administration & dosage/antagonists & inhibitors/*toxicity
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Fetal Growth Retardation/chemically induced/prevention & control
MH  - Folic Acid/*administration & dosage/blood/therapeutic use
MH  - Gestational Age
MH  - Homocysteine/blood/drug effects
MH  - Mice
MH  - Pregnancy
MH  - Vitamin B 12/*administration & dosage/blood/therapeutic use
EDAT- 2006/01/28 09:00
MHDA- 2006/09/26 09:00
CRDT- 2006/01/28 09:00
PHST- 2005/08/17 00:00 [received]
PHST- 2005/11/24 00:00 [revised]
PHST- 2005/12/06 00:00 [accepted]
PHST- 2006/01/28 09:00 [pubmed]
PHST- 2006/09/26 09:00 [medline]
PHST- 2006/01/28 09:00 [entrez]
AID - S0890-6238(05)00274-1 [pii]
AID - 10.1016/j.reprotox.2005.12.004 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2006 Jul;22(1):56-61. doi: 10.1016/j.reprotox.2005.12.004. Epub 
      2006 Jan 24.