PMID- 16441480
OWN - NLM
STAT- MEDLINE
DCOM- 20060613
LR  - 20061115
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 67
IP  - 2
DP  - 2006 Feb
TI  - HLA class II disease associations in southern Africa.
PG  - 97-110
AB  - Southern Africa harbors several population groups representing a diversity of 
      gene pool origins. This provides a unique opportunity to study genetic disease 
      predisposition in these populations against a common environmental background. 
      Human leukocyte antigen (HLA) association studies of these populations could 
      improve knowledge on inter-population variation and HLA-related disease 
      susceptibility. The aim of this paper is to review HLA class II disease 
      associations reported for southern African population groups, compare them with 
      findings in other populations and identify those unique to southern Africa. A 
      number of HLA class II disease associations appear to be unique to southern 
      African populations. These include DRB1*14011 association with insulin-dependent 
      diabetes mellitus susceptibility in the Xhosa and DRB1*10 and DQB1*0302 with 
      rheumatoid arthritis susceptibility in the South African (SA) Indian and SA 
      Coloreds, respectively. A noteworthy similarity in class II disease association 
      was observed among southern African Caucasoid and their European parental 
      populations. Unique HLA class II disease associations observed in southern Africa 
      are consistent with the notion that unique environmental and natural selective 
      factors have resulted in certain ethnic-specific HLA class II disease 
      associations, while common HLA class II disease associations found across 
      different populations support the notion that common diseases are caused by 
      common, ancient alleles present in indigenous African populations.
FAU - Lombard, Z
AU  - Lombard Z
AD  - Department of Biochemistry, University of Johannesburg, PO Box 524, Auckland Park 
      2006, South Africa.
FAU - Brune, A E
AU  - Brune AE
FAU - Hoal, E G
AU  - Hoal EG
FAU - Babb, C
AU  - Babb C
FAU - Van Helden, P D
AU  - Van Helden PD
FAU - Epplen, J T
AU  - Epplen JT
FAU - Bornman, L
AU  - Bornman L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Africa, Southern/epidemiology
MH  - Arthritis, Rheumatoid/epidemiology/*genetics/immunology
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics/immunology
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*epidemiology
MH  - HIV Infections/epidemiology/genetics/immunology
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Mycobacterium Infections/epidemiology/*genetics/immunology
MH  - Polymorphism, Genetic
RF  - 92
EDAT- 2006/01/31 09:00
MHDA- 2006/06/14 09:00
CRDT- 2006/01/31 09:00
PHST- 2006/01/31 09:00 [pubmed]
PHST- 2006/06/14 09:00 [medline]
PHST- 2006/01/31 09:00 [entrez]
AID - TAN530 [pii]
AID - 10.1111/j.1399-0039.2006.00530.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2006 Feb;67(2):97-110. doi: 10.1111/j.1399-0039.2006.00530.x.