PMID- 16441967
OWN - NLM
STAT- MEDLINE
DCOM- 20061213
LR  - 20220317
IS  - 0021-9320 (Print)
IS  - 0021-9320 (Linking)
VI  - 38
IP  - 6
DP  - 2006 Nov
TI  - Social networks and inflammatory markers in the Framingham Heart Study.
PG  - 835-42
AB  - Lack of social integration predicts coronary heart disease mortality in 
      prospective studies; however, the biological pathways that may be responsible are 
      poorly understood. The specific aims of this study were to examine whether social 
      networks are associated with serum concentrations of the inflammatory markers 
      interleukin-6 (IL-6), C-reactive protein (CRP), soluble intercellular adhesion 
      molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1). Participants 
      in the Framingham Study attending examinations from 1998 to 2001 (n=3267) were 
      eligible for inclusion in the study. Social networks were assessed using the 
      Berkman-Syme Social Network Index (SNI). Concentrations of IL-6, CRP, sICAM-1 and 
      MCP-1 were measured in fasting serum samples. Multivariable linear regression 
      analyses were used to assess the association of social networks with inflammatory 
      markers adjusting for potential confounders including age, smoking, blood 
      pressure, total:HDL cholesterol ratio, body mass index, lipid-lowering and 
      antihypertensive medication, diabetes, cardiovascular disease, depression and 
      socioeconomic status. Results found that the SNI was significantly inversely 
      associated with IL-6 in men (p=0.03) after adjusting for potential confounders. 
      In age-adjusted analyses, social networks also were significantly inversely 
      associated with IL-6 for women (p=0.03) and were marginally to modestly 
      associated with CRP and sICAM-1 for men (p=0.08 and 0.02, respectively), but 
      these associations were not significant in the multivariate analyses. In 
      conclusion, social networks were found to be inversely associated with 
      interleukin-6 levels in men. The possibility that inflammatory markers may be 
      potential mediators between social integration and coronary heart disease merits 
      further investigation.
FAU - Loucks, Eric B
AU  - Loucks EB
AD  - Department of Society, Human Development & Health, Harvard School of Public 
      Health, Boston, MA, USA.
FAU - Sullivan, Lisa M
AU  - Sullivan LM
FAU - D'Agostino, Ralph B Sr
AU  - D'Agostino RB Sr
FAU - Larson, Martin G
AU  - Larson MG
FAU - Berkman, Lisa F
AU  - Berkman LF
FAU - Benjamin, Emelia J
AU  - Benjamin EJ
LA  - eng
GR  - HL64753/HL/NHLBI NIH HHS/United States
GR  - HL76784/HL/NHLBI NIH HHS/United States
GR  - N01-HC-25195/HC/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060127
PL  - England
TA  - J Biosoc Sci
JT  - Journal of biosocial science
JID - 0177346
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Biomarkers
MH  - C-Reactive Protein/metabolism
MH  - Chemokine CCL2/blood
MH  - Coronary Disease/*blood/epidemiology/*psychology
MH  - Female
MH  - Humans
MH  - Inflammation/*blood
MH  - Intercellular Adhesion Molecule-1/blood
MH  - Interleukin-6/blood
MH  - *Interpersonal Relations
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Social Support
MH  - United States/epidemiology
EDAT- 2006/01/31 09:00
MHDA- 2006/12/14 09:00
CRDT- 2006/01/31 09:00
PHST- 2006/01/31 09:00 [pubmed]
PHST- 2006/12/14 09:00 [medline]
PHST- 2006/01/31 09:00 [entrez]
AID - S0021932005001203 [pii]
AID - 10.1017/S0021932005001203 [doi]
PST - ppublish
SO  - J Biosoc Sci. 2006 Nov;38(6):835-42. doi: 10.1017/S0021932005001203. Epub 2006 
      Jan 27.