PMID- 16442082
OWN - NLM
STAT- MEDLINE
DCOM- 20060628
LR  - 20220318
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 59
IP  - 9
DP  - 2006 May 1
TI  - BDNF Val66Met allele is associated with reduced hippocampal volume in healthy 
      subjects.
PG  - 812-5
AB  - BACKGROUND: A frequent polymorphism of the brain-derived neurotrophic factor 
      (BDNF) gene (val(66)met) has been suggested to modulate hippocampal neuronal 
      plasticity and has been associated with individual variations in emotional 
      reactivity traits and episodic memory. METHODS: The hippocampal formation was 
      outlined in high-resolution anatomical magnetic resonance imaging (MRI) data in a 
      sample of 36 healthy volunteers and compared between individuals as a function of 
      the presence of the met-BDNF allele. Both whole-brain volume corrected and 
      uncorrected data were tested for effects of genotype, sex, and age. RESULTS: The 
      met-BDNF allele was associated with an 11% reduction in the volume of the 
      hippocampal formation. CONCLUSIONS: In spite of a relatively small sample size, 
      the presence of the met-BDNF allele was found associated with a reduced volume of 
      the hippocampal formation in healthy volunteers and may represent a vulnerability 
      factor for the development of disease processes associated with the dysfunction 
      of this brain region.
FAU - Bueller, Joshua A
AU  - Bueller JA
AD  - Mental Health Research Institute, The University of Michigan, Ann Arbor, 
      Michigan, USA.
FAU - Aftab, Macksood
AU  - Aftab M
FAU - Sen, Srijan
AU  - Sen S
FAU - Gomez-Hassan, Diana
AU  - Gomez-Hassan D
FAU - Burmeister, Margit
AU  - Burmeister M
FAU - Zubieta, Jon-Kar
AU  - Zubieta JK
LA  - eng
GR  - R01 DA 016423/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060125
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Alleles
MH  - Analysis of Variance
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Functional Laterality/genetics
MH  - Genotype
MH  - Hippocampus/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic/genetics
MH  - Valine/*genetics
EDAT- 2006/01/31 09:00
MHDA- 2006/06/29 09:00
CRDT- 2006/01/31 09:00
PHST- 2005/02/02 00:00 [received]
PHST- 2005/08/22 00:00 [revised]
PHST- 2005/09/30 00:00 [accepted]
PHST- 2006/01/31 09:00 [pubmed]
PHST- 2006/06/29 09:00 [medline]
PHST- 2006/01/31 09:00 [entrez]
AID - S0006-3223(05)01371-5 [pii]
AID - 10.1016/j.biopsych.2005.09.022 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2006 May 1;59(9):812-5. doi: 10.1016/j.biopsych.2005.09.022. 
      Epub 2006 Jan 25.