PMID- 16442252
OWN - NLM
STAT- MEDLINE
DCOM- 20061129
LR  - 20060529
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 106
IP  - 2
DP  - 2006 Jun 30
TI  - Effects of Liuwei Dihuang decoction on ion channels and synaptic transmission in 
      cultured hippocampal neuron of rat.
PG  - 166-72
AB  - The effect of Liuwei Dihuang decoction (LW), a traditional Chinese medicine (TCM) 
      prescription, on voltage-dependent currents and synaptic transmission were 
      investigated in cultured hippocampal neurons of rat by whole-cell patch clamp 
      recording technique. After application with serum from LW-treated rats, termed 
      LW-containing serum (LWCS) for 48 h, the amplitude of delay rectifying K+ current 
      (IK) and voltage-gated Ca2+ current (ICa) decreased. While the frequency of 
      spontaneous excitatory post-synaptic current (sEPSC) and miniature excitatory 
      post-synaptic current (mEPSC) increased significantly. Yet the amplitude of 
      voltage-depended Na+ current (INa) and transient outward K+ current (IA), 
      membrane capacitance and resistance remained unchanged. The results indicated 
      that LWCS possessed the effect of modulating or improving neuronal and synaptic 
      function, which possibly contribute to the cognition enhancing effect of LW.
FAU - Yang, Sheng
AU  - Yang S
AD  - Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
FAU - Zhou, Wenxia
AU  - Zhou W
FAU - Zhang, Yongxiang
AU  - Zhang Y
FAU - Yan, Cunyu
AU  - Yan C
FAU - Zhao, Yimin
AU  - Zhao Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060124
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Calcium Channels)
RN  - 0 (Delayed Rectifier Potassium Channels)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Ion Channels)
RN  - 0 (Liuwei Dihuang Decoction)
RN  - 0 (Sodium Channels)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Calcium Channels/drug effects
MH  - Cells, Cultured
MH  - Delayed Rectifier Potassium Channels/drug effects
MH  - Drugs, Chinese Herbal/administration & dosage/*pharmacology
MH  - Electric Capacitance
MH  - Electric Impedance
MH  - Excitatory Postsynaptic Potentials/drug effects
MH  - Hippocampus/cytology/*drug effects/metabolism
MH  - Ion Channel Gating/drug effects
MH  - Ion Channels/*drug effects/metabolism
MH  - Male
MH  - Membrane Potentials/drug effects
MH  - Neurons/*drug effects/metabolism
MH  - Patch-Clamp Techniques
MH  - Rats
MH  - Rats, Wistar
MH  - Serum/metabolism
MH  - Sodium Channels/drug effects
MH  - Synaptic Transmission/*drug effects
EDAT- 2006/01/31 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/01/31 09:00
PHST- 2004/11/01 00:00 [received]
PHST- 2005/10/17 00:00 [revised]
PHST- 2005/12/13 00:00 [accepted]
PHST- 2006/01/31 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/01/31 09:00 [entrez]
AID - S0378-8741(05)00836-6 [pii]
AID - 10.1016/j.jep.2005.12.017 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2006 Jun 30;106(2):166-72. doi: 10.1016/j.jep.2005.12.017. Epub 
      2006 Jan 24.