PMID- 16442731
OWN - NLM
STAT- MEDLINE
DCOM- 20060510
LR  - 20071114
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 398
IP  - 1-2
DP  - 2006 May 1
TI  - Sex difference in Fos induced by male urine in medial amygdala-projecting 
      accessory olfactory bulb mitral cells of mice.
PG  - 59-62
AB  - We previously reported that exposure to soiled male bedding induced Fos protein 
      immunoreactivity (Fos-IR) in significantly more neurons of the vomeronasal organ 
      (VNO) and medial amygdala of gonadectomized, estradiol-treated female than male 
      mice whereas no such sex difference was seen in the intervening mitral cells of 
      the accessory olfactory bulb (AOB). We asked whether a sexually dimorphic 
      functional response to male urinary pheromones might be revealed in AOB mitral 
      cells that project specifically to the medial amygdala. Gonadectomized mice of 
      both sexes were treated with estradiol and 3 days later received bilateral 
      injections of the retrograde tracer, Cholera toxin-B (CTB) into the medial 
      amygdala. Five days later male urine or saline was applied nasally to each 
      subject 90 min prior to sacrifice, and sections of the AOB were processed for 
      double-label fluorescent immunocytochemistry for Fos protein and CTB. In both the 
      rostral and caudal AOB, there were significantly more double-labeled mitral cells 
      in female than in male subjects following exposure to male urine. A sex 
      difference in the responsiveness of VNO sensory neurons seen previously to male 
      soiled bedding is reflected in a parallel sex difference in the responsiveness of 
      AOB mitral cells when only AOB cells that project to the amygdala are examined 
      and when male urine as opposed to soiled male bedding is used as the activating 
      stimulus.
FAU - Kang, Ningdong
AU  - Kang N
AD  - Department of Biology, Boston University, Boston, MA 02215, USA.
FAU - Janes, Amy
AU  - Janes A
FAU - Baum, Michael J
AU  - Baum MJ
FAU - Cherry, James A
AU  - Cherry JA
LA  - eng
GR  - MH59200/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060118
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Indicators and Reagents)
RN  - 0 (Pheromones)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 9012-63-9 (Cholera Toxin)
SB  - IM
MH  - Amygdala/*physiology
MH  - Animals
MH  - Castration
MH  - Cholera Toxin
MH  - Female
MH  - Immunohistochemistry
MH  - Indicators and Reagents
MH  - Male
MH  - Mice
MH  - Olfactory Bulb/cytology/*metabolism
MH  - Pheromones/*physiology
MH  - Proto-Oncogene Proteins c-fos/*biosynthesis
MH  - *Sex Characteristics
MH  - Urine
EDAT- 2006/01/31 09:00
MHDA- 2006/05/11 09:00
CRDT- 2006/01/31 09:00
PHST- 2005/10/31 00:00 [received]
PHST- 2005/12/14 00:00 [revised]
PHST- 2005/12/16 00:00 [accepted]
PHST- 2006/01/31 09:00 [pubmed]
PHST- 2006/05/11 09:00 [medline]
PHST- 2006/01/31 09:00 [entrez]
AID - S0304-3940(05)01453-9 [pii]
AID - 10.1016/j.neulet.2005.12.062 [doi]
PST - ppublish
SO  - Neurosci Lett. 2006 May 1;398(1-2):59-62. doi: 10.1016/j.neulet.2005.12.062. Epub 
      2006 Jan 18.