PMID- 16443358
OWN - NLM
STAT- MEDLINE
DCOM- 20060905
LR  - 20210224
IS  - 0955-2863 (Print)
IS  - 0955-2863 (Linking)
VI  - 17
IP  - 8
DP  - 2006 Aug
TI  - Modulation of hepatic phase II phenol sulfotransferase and antioxidant status by 
      phenolic acids in rats.
PG  - 561-9
AB  - Phenolic acids have significant biological and pharmacological properties and 
      some have demonstrated remarkable ability to alter sulfate conjugation. However, 
      the modulatory effects of phenolic acids on phenol sulfotransferases (PSTs) in 
      vivo have not been described. The present investigation evaluates the role of 
      phenolic acid on the expression of PSTs in male Sprague-Dawley rat liver. 
      According to the results, gentisic acid, gallic acid and p-coumaric acid in a 
      dosage of 100 mg/kg of body weight for 14 consecutive days significantly 
      increased P-form PST (PST-P) activity as compared with that of the control rats 
      (P<.05), whereas the activity of M-form PST (PST-M) in rats that received gallic 
      acid and p-coumaric acid were also significantly (P<.05) higher than in the 
      control rats. Reverse transcriptase-polymerase chain reaction results indicated 
      that the changes in both PST-P and PST-M mRNA levels by phenolic acids were 
      similar to those noted in the enzyme activity levels. The plasma obtained from 
      phenolic acid-administered rats had significantly (P<.05) increased oxygen 
      radical absorbance capacity (ORAC(ROO*) values than that from control rats. In a 
      bioavailability study, following oral administration of gallic acid and 
      p-coumaric acid, the phenolic acids were detected in the plasma, and the Cmax 
      values after 2.0-h administration were 665+/-23 and 550+/-33 nmol/L, 
      respectively. There was a significant correlation between the activity of both 
      forms of PSTs and the antioxidant capacity of ORAC(ROO*) value by phenolic acids 
      (r=.74, P<.05 and r=.77, P<.05). These data suggest that phenolic acids might 
      alter sulfate conjugation and antioxidant capacity in living systems.
FAU - Yeh, Chi-Tai
AU  - Yeh CT
AD  - Department of Food Science and Biotechnology, National Chung Hsing University, 
      250 Kuokuang Road, Taichung 40227, Taiwan.
FAU - Yen, Gow-Chin
AU  - Yen GC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051110
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Acids, Carbocyclic)
RN  - 0 (Antioxidants)
RN  - 0 (Coumaric Acids)
RN  - 0 (Gentisates)
RN  - 0 (Propionates)
RN  - 0 (RNA, Messenger)
RN  - 632XD903SP (Gallic Acid)
RN  - AVM951ZWST (ferulic acid)
RN  - EC 2.8.2.1 (Arylsulfotransferase)
RN  - IBS9D1EU3J (p-coumaric acid)
RN  - VP36V95O3T (2,5-dihydroxybenzoic acid)
SB  - IM
EIN - J Nutr Biochem. 2013 Nov;24(11):2001
MH  - Acids, Carbocyclic/*administration & dosage
MH  - Animals
MH  - Antioxidants/*analysis
MH  - Arylsulfotransferase/genetics/*metabolism
MH  - Biological Availability
MH  - Chromatography, High Pressure Liquid
MH  - Coumaric Acids/administration & dosage/pharmacokinetics
MH  - Gallic Acid/administration & dosage/pharmacokinetics
MH  - Gene Expression/drug effects
MH  - Gentisates/administration & dosage
MH  - Liver/anatomy & histology/*enzymology
MH  - Male
MH  - Organ Size/drug effects
MH  - Propionates
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2006/01/31 09:00
MHDA- 2006/09/06 09:00
CRDT- 2006/01/31 09:00
PHST- 2005/08/20 00:00 [received]
PHST- 2005/10/04 00:00 [revised]
PHST- 2005/10/11 00:00 [accepted]
PHST- 2006/01/31 09:00 [pubmed]
PHST- 2006/09/06 09:00 [medline]
PHST- 2006/01/31 09:00 [entrez]
AID - S0955-2863(05)00272-X [pii]
AID - 10.1016/j.jnutbio.2005.10.008 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2006 Aug;17(8):561-9. doi: 10.1016/j.jnutbio.2005.10.008. Epub 
      2005 Nov 10.