PMID- 16443546
OWN - NLM
STAT- MEDLINE
DCOM- 20060524
LR  - 20181113
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 83
IP  - 1
DP  - 2006 Jan
TI  - CD4+CD3- cells regulate the organization of lymphoid tissue and T-cell memory for 
      antibody responses.
PG  - 12-6
AB  - This review highlights the role of a CD4(+)CD3(-) accessory cell in the 
      development of organized lymphoid infrastructures as well as in the development 
      of high-affinity antibody responses and T-cell memory. These 2 functions are 
      linked in the development of the vertebrate immune system and are effected by the 
      constitutive expression of 2 sets of tumor necrosis factor (TNF) family members. 
      The expression of lymphotoxin 3 (LT3), LT3, and TNF-3, which are closely linked 
      genetically, affects the organization of lymphoid structures into B-cell and 
      T-cell areas; the dual expression of OX40 ligand (TNFSF4) and CD30 ligand 
      (TNFSF8) influences both the survival of T-cells within germinal centers and 
      T-cell memory.
FAU - Lane, Peter J L
AU  - Lane PJ
AD  - MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham 
      Medical School, Birmingham, UK. p.j.l.lane@bham.ac.uk
FAU - Kim, Mi-Yeon
AU  - Kim MY
FAU - Gaspal, Fabrina M C
AU  - Gaspal FM
FAU - McConnell, Fiona M
AU  - McConnell FM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (CD3 Complex)
RN  - 0 (Lymphotoxin-alpha)
SB  - IM
MH  - Animals
MH  - *Antibody Formation
MH  - B-Lymphocytes/immunology
MH  - CD3 Complex/genetics/*immunology
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Chromosomes, Human/genetics/immunology
MH  - Germinal Center/*immunology
MH  - Humans
MH  - Immunologic Memory/genetics/*immunology
MH  - Lymphotoxin-alpha/immunology
RF  - 20
EDAT- 2006/01/31 09:00
MHDA- 2006/05/25 09:00
CRDT- 2006/01/31 09:00
PHST- 2006/01/31 09:00 [pubmed]
PHST- 2006/05/25 09:00 [medline]
PHST- 2006/01/31 09:00 [entrez]
AID - F08QB16G07QUY3YJ [pii]
AID - 10.1532/IJH97.05117 [doi]
PST - ppublish
SO  - Int J Hematol. 2006 Jan;83(1):12-6. doi: 10.1532/IJH97.05117.