PMID- 16443747
OWN - NLM
STAT- MEDLINE
DCOM- 20060613
LR  - 20220331
IS  - 0021-9533 (Print)
IS  - 0021-9533 (Linking)
VI  - 119
IP  - Pt 3
DP  - 2006 Feb 1
TI  - Wnt signaling: complexity at the surface.
PG  - 395-402
AB  - Wnts are secreted proteins that are essential for a wide array of developmental 
      and physiological processes. They signal across the plasma membrane by 
      interacting with serpentine receptors of the Frizzled (Fz) family and members of 
      the low-density-lipoprotein-related protein (LRP) family. Activation of Fz-LRP 
      promotes the stability and nuclear localization of beta-catenin by compromising 
      the ability of a multiprotein complex containing axin, adenomatosis polyposis 
      coli (APC) and glycogen synthase kinase 3 (GSK3) to target it for degradation and 
      block its nuclear import. The Fz-LRP receptor complex probably accomplishes this 
      by generating multiple signals in the cytoplasm. These involve activation of 
      Dishevelled (Dsh), possibly through trimeric G proteins and LRP-mediated axin 
      binding and/or degradation. However, individual Wnts and Fzs can activate both 
      beta-catenin-dependent and -independent pathways, and Fz co-receptors such as LRP 
      probably provide some of this specificity. Additional, conflicting data concern 
      the role of the atypical receptor tyrosine kinase Ryk, which might mediate Wnt 
      signaling independently of Fz and/or function as a Fz co-receptor in some cells.
FAU - Cadigan, Ken M
AU  - Cadigan KM
AD  - Department of Molecular, Cellular and Developmental Biology, University of 
      Michigan, Natural Science Building, Ann Arbor, MI 48109-1048, USA. 
      cadigan@umich.edu
FAU - Liu, Yan I
AU  - Liu YI
LA  - eng
GR  - CA95869/CA/NCI NIH HHS/United States
GR  - R01 GM59846/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
RN  - 0 (Low Density Lipoprotein Receptor-Related Protein-1)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 0 (Wnt Proteins)
SB  - IM
MH  - Active Transport, Cell Nucleus/physiology
MH  - Animals
MH  - Cell Nucleus/metabolism
MH  - Humans
MH  - Low Density Lipoprotein Receptor-Related Protein-1/metabolism
MH  - Multiprotein Complexes/metabolism
MH  - Receptors, Neurotransmitter/metabolism
MH  - Signal Transduction/*physiology
MH  - Wnt Proteins/*metabolism
RF  - 131
EDAT- 2006/01/31 09:00
MHDA- 2006/06/14 09:00
CRDT- 2006/01/31 09:00
PHST- 2006/01/31 09:00 [pubmed]
PHST- 2006/06/14 09:00 [medline]
PHST- 2006/01/31 09:00 [entrez]
AID - 119/3/395 [pii]
AID - 10.1242/jcs.02826 [doi]
PST - ppublish
SO  - J Cell Sci. 2006 Feb 1;119(Pt 3):395-402. doi: 10.1242/jcs.02826.