PMID- 1644437 OWN - NLM STAT- MEDLINE DCOM- 19920908 LR - 20190722 IS - 0046-8177 (Print) IS - 0046-8177 (Linking) VI - 23 IP - 8 DP - 1992 Aug TI - Ectopic somatic endoderm in secondary human yolk sac. PG - 921-4 AB - Three secondary human yolk sacs (SHYSs) showing heterotopic endodermal tubular structures of the gut-forming type were analyzed from a series of 180 SHYSs. These structures were similar to the early somatic endoderm involved in the formation of gut and lung. They may have arisen either as sequestrations in growth-disorganized embryos or as a phenomenon of differentiation from extraembryonal endoderm, which would indicate that extraembryonal tissues such as the SHYSs retain the capacity to differentiate somatic endoderm in developmentally altered embryos. It is possible that these structures may be the precursors of placental hepatic tissue and teratomas. Their morphologic resemblance to similar structures found in glandular, polyvesicular, and intestinal human yolk sac tumors provides yet another example of the similarity between SHYSs and yolk sac tumors. FAU - Nogales, F F AU - Nogales FF AD - Department of Pathology, University of Granada School of Medicine, Spain. FAU - Beltran, E AU - Beltran E FAU - Pavcovich, M AU - Pavcovich M FAU - Bustos, M AU - Bustos M LA - eng PT - Journal Article PL - United States TA - Hum Pathol JT - Human pathology JID - 9421547 SB - IM MH - Abortion, Spontaneous MH - Adult MH - Cell Transformation, Neoplastic/pathology MH - Digestive System/embryology MH - Endoderm/*pathology MH - Female MH - Humans MH - Lung/embryology MH - Mesonephroma/etiology/*pathology MH - Ovarian Neoplasms/etiology/*pathology MH - Pregnancy MH - Yolk Sac/*pathology EDAT- 1992/08/01 00:00 MHDA- 1992/08/01 00:01 CRDT- 1992/08/01 00:00 PHST- 1992/08/01 00:00 [pubmed] PHST- 1992/08/01 00:01 [medline] PHST- 1992/08/01 00:00 [entrez] AID - 0046-8177(92)90406-S [pii] AID - 10.1016/0046-8177(92)90406-s [doi] PST - ppublish SO - Hum Pathol. 1992 Aug;23(8):921-4. doi: 10.1016/0046-8177(92)90406-s.