PMID- 16445577
OWN - NLM
STAT- MEDLINE
DCOM- 20060317
LR  - 20190107
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 32
IP  - 12
DP  - 2005 Dec
TI  - Beneficial effect of laserpitin, a coumarin compound from Angelica keiskei, on 
      lipid metabolism in stroke-prone spontaneously hypertensive rats.
PG  - 1104-9
AB  - Recently, we found that 4-hydroxyderricin, one of the major chalcones in Angelica 
      keiskei extract (an ethyl acetate extract from the yellow liquid of stems), 
      suppressed increases in systolic blood pressure and reduced both serum very 
      low-density lipoprotein levels and liver triglyceride content in stroke-prone 
      spontaneously hypertensive rats (SHRSP). In the present study, we have isolated 
      laserpitin, a characteristic coumarin, from the A. keiskei extract and examined 
      the effect of dietary laserpitin on blood pressure and lipid metabolism in SHRSP. 
      Six-week-old male SHRSP were fed diets containing 0.1% laserpitin for 7 weeks 
      with free access to the diet and water. Bodyweight gain was reduced by dietary 
      laserpitin after 4 weeks through to 7 weeks without any significant change in 
      daily food intake. Serum total cholesterol, phospholipid and apolipoprotein (apo) 
      E levels were significantly increased, which was due to significant increases in 
      cholesterol, phospholipid and apoE contents in the low- and high-density 
      lipoprotein (LDL and HDL, respectively) fractions. These results suggest that 
      dietary laserpitin increases serum apoE-HDL levels. In the liver, significant 
      decreases in relative liver weight and triglyceride content were found after 
      treatment with laserpitin for 7 weeks. An investigation of hepatic mRNA 
      expression of proteins involved in lipid metabolism indicated that a significant 
      decrease in hepatic triglyceride lipase may be responsible for the increase in 
      serum HDL levels and also indicated that a marked decrease in adipocyte 
      determination and differentiation factor 1 may be responsible, at least in part, 
      for the decrease in hepatic triglyceride content. In conclusion, dietary 
      laserpitin produces increases in serum HDL levels, especially apoE-HDL, and 
      decreases in the hepatic triglyceride content in SHRSP.
FAU - Ogawa, Hiroshi
AU  - Ogawa H
AD  - Department of Hygiene, Kinki University School of Medicine, Osaka-Sayama City, 
      Osaka, Japan. ogawa-h@med.kindai.ac.jp
FAU - Nakamura, Rei
AU  - Nakamura R
FAU - Baba, Kimiye
AU  - Baba K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Apolipoproteins)
RN  - 0 (Coumarins)
RN  - 0 (Lipoproteins)
RN  - 0 (RNA, Messenger)
RN  - EC 1.14.14.23 (Cholesterol 7-alpha-Hydroxylase)
RN  - F35AHK6206 (laserpitin)
SB  - IM
MH  - Angelica/*chemistry
MH  - Animals
MH  - Apolipoproteins/metabolism
MH  - Blood Pressure/drug effects
MH  - Cholesterol 7-alpha-Hydroxylase/metabolism
MH  - Coumarins/chemistry/*pharmacology
MH  - Diet
MH  - Lipid Metabolism/*drug effects
MH  - Lipoproteins/metabolism
MH  - Liver/drug effects/enzymology/metabolism
MH  - Organ Size/drug effects
MH  - Plant Stems/chemistry
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Stroke/metabolism
EDAT- 2006/02/01 09:00
MHDA- 2006/03/18 09:00
CRDT- 2006/02/01 09:00
PHST- 2006/02/01 09:00 [pubmed]
PHST- 2006/03/18 09:00 [medline]
PHST- 2006/02/01 09:00 [entrez]
AID - CEP4306 [pii]
AID - 10.1111/j.1440-1681.2005.04306.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1104-9. doi: 
      10.1111/j.1440-1681.2005.04306.x.