PMID- 16445652
OWN - NLM
STAT- MEDLINE
DCOM- 20060517
LR  - 20181030
IS  - 1048-891X (Print)
IS  - 1048-891X (Linking)
VI  - 16
IP  - 1
DP  - 2006 Jan-Feb
TI  - Detection of chromosomal aberrations by fluorescence in situ hybridization in 
      cervicovaginal biopsies from women exposed to diethylstilbestrol in utero.
PG  - 318-24
AB  - Epidemiologic studies have associated estrogens with human neoplasms such as 
      those in the endometrium, cervix, vagina, breast, and liver. Perinatal exposure 
      to natural (17beta-estradiol [17beta-E(2)]) and synthetic (diethylstilbestrol 
      [DES]) estrogens induces neoplastic changes in humans and rodents. Previous 
      studies demonstrated that neonatal 17beta-E(2) treatment of mice results in 
      increased nuclear DNA content of cervicovaginal epithelium that precedes 
      histologically evident neoplasia. In order to determine whether this effect was 
      associated with chromosomal changes in humans, the frequencies of trisomy of 
      chromosomes 1, 7, 11, and 17 were evaluated by the fluorescence in situ 
      hybridization (FISH) technique in cervicovaginal tissue from 19 DES-exposed and 
      19 control women. The trisomic frequencies were significantly elevated in 4 of 
      the 19 (21%) DES-exposed patients. One patient presented with trisomy of 
      chromosomes 1, 7, and 11, while trisomy of chromosome 7 was observed in one 
      patient. There were two patients with trisomy of chromosome 1. Trisomy of 
      chromosomes 1, 7, 11, and 17 was not observed in the cervicovaginal tissue taken 
      from control patients. These data suggest that DES-induced chromosomal trisomy 
      may be an early event in the development of cervicovaginal neoplasia in humans.
FAU - Hajek, R A
AU  - Hajek RA
AD  - Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer 
      Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. rhajek@mdanderson.org
FAU - King, D W
AU  - King DW
FAU - Hernandez-Valero, M A
AU  - Hernandez-Valero MA
FAU - Kaufman, R H
AU  - Kaufman RH
FAU - Liang, J C
AU  - Liang JC
FAU - Chilton, J A
AU  - Chilton JA
FAU - Edwards, C L
AU  - Edwards CL
FAU - Wharton, J T
AU  - Wharton JT
FAU - Jones, L A
AU  - Jones LA
LA  - eng
GR  - P30 CA 16672/CA/NCI NIH HHS/United States
GR  - P60 MD 00503/MD/NIMHD NIH HHS/United States
GR  - R01 CA 44591/CA/NCI NIH HHS/United States
GR  - R01 CA 69375A-05S4/CA/NCI NIH HHS/United States
GR  - T32 HD 07324/HD/NICHD NIH HHS/United States
GR  - U48 CCU 619515-01/CC/ODCDC CDC HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Gynecol Cancer
JT  - International journal of gynecological cancer : official journal of the 
      International Gynecological Cancer Society
JID - 9111626
RN  - 731DCA35BT (Diethylstilbestrol)
SB  - IM
MH  - Adenocarcinoma, Clear Cell/chemically induced/epidemiology/pathology
MH  - Adult
MH  - Biopsy, Needle
MH  - Case-Control Studies
MH  - Chromosome Aberrations/*chemically induced/statistics & numerical data
MH  - Diethylstilbestrol/*adverse effects/therapeutic use
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Incidence
MH  - Probability
MH  - Reference Values
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Tissue Culture Techniques
MH  - *Trisomy
MH  - Uterine Cervical Neoplasms/chemically induced/epidemiology/pathology
MH  - Uterus/*drug effects
MH  - Vaginal Neoplasms/chemically induced/epidemiology/pathology
EDAT- 2006/02/01 09:00
MHDA- 2006/05/18 09:00
CRDT- 2006/02/01 09:00
PHST- 2006/02/01 09:00 [pubmed]
PHST- 2006/05/18 09:00 [medline]
PHST- 2006/02/01 09:00 [entrez]
AID - IJG338 [pii]
AID - 10.1111/j.1525-1438.2006.00338.x [doi]
PST - ppublish
SO  - Int J Gynecol Cancer. 2006 Jan-Feb;16(1):318-24. doi: 
      10.1111/j.1525-1438.2006.00338.x.