PMID- 16445900
OWN - NLM
STAT- MEDLINE
DCOM- 20060831
LR  - 20071115
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 368
IP  - 1-2
DP  - 2006 Jun
TI  - The influence of HIV infection on the correlation between plasma concentrations 
      of monocyte chemoattractant protein-1 and carotid atherosclerosis.
PG  - 114-9
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) plays a crucial role in 
      atherosclerosis and it has been recently proposed as a surrogate biomarker of 
      long-term clinical outcomes in patients with acute myocardial infarction. Little 
      is known of the factors that may influence plasma MCP-1 concentrations. METHODS: 
      We studied 384 healthy volunteers and 226 HIV-infected patients as a model of 
      chronic inflammatory condition that predisposes to sub-clinical atherosclerosis. 
      RESULTS: In healthy participants there were significant associations between 
      plasma MCP-1 concentration and age, smoking status, and serum triglyceride 
      concentrations that were not observed in the HIV-infected patients. The plasma 
      concentration of MCP-1 was significantly associated with the polymorphism at 
      position -2518 of the MCP-1 gene and, in patients, with the carotid artery 
      intima-media thickness. There were also significant correlations indicating a 
      close association between MCP-1 and HIV disease activity. However, in a multiple 
      regression model, only age, the MCP-1 genotype and smoking status showed 
      significant, and independent, associations with plasma MCP-1 concentrations. 
      CONCLUSION: Plasma MCP-1 concentration is genetically determined and associated 
      with age and smoking habit and it also correlates with subclinical 
      atherosclerosis in HIV-infected patients.
FAU - Joven, Jorge
AU  - Joven J
AD  - Centre de Recerca Biomedica dels Laboratoris Clinics, Hospital Universitari de 
      Sant Joan, Institut de Recerca en Ciencies de la Salut, C. Sant Joan s/n, 43201 
      Reus, Spain.
FAU - Coll, Blai
AU  - Coll B
FAU - Tous, Monica
AU  - Tous M
FAU - Ferre, Natalia
AU  - Ferre N
FAU - Alonso-Villaverde, Carlos
AU  - Alonso-Villaverde C
FAU - Parra, Sandra
AU  - Parra S
FAU - Camps, Jordi
AU  - Camps J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060130
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/*blood
MH  - Coronary Artery Disease/*blood/*complications/genetics/pathology
MH  - Female
MH  - Genotype
MH  - HIV/*physiology
MH  - HIV Infections/*blood/*complications/genetics/virology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/genetics
MH  - Receptors, CCR2
MH  - Receptors, Chemokine/genetics
MH  - Risk Factors
EDAT- 2006/02/01 09:00
MHDA- 2006/09/01 09:00
CRDT- 2006/02/01 09:00
PHST- 2005/10/21 00:00 [received]
PHST- 2005/12/15 00:00 [revised]
PHST- 2005/12/15 00:00 [accepted]
PHST- 2006/02/01 09:00 [pubmed]
PHST- 2006/09/01 09:00 [medline]
PHST- 2006/02/01 09:00 [entrez]
AID - S0009-8981(05)00724-2 [pii]
AID - 10.1016/j.cca.2005.12.014 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2006 Jun;368(1-2):114-9. doi: 10.1016/j.cca.2005.12.014. Epub 
      2006 Jan 30.