PMID- 16445989
OWN - NLM
STAT- MEDLINE
DCOM- 20061004
LR  - 20090928
IS  - 0165-0327 (Print)
IS  - 0165-0327 (Linking)
VI  - 91
IP  - 1
DP  - 2006 Mar
TI  - Association of psychosis with suicidality in pediatric bipolar I, II and bipolar 
      NOS patients.
PG  - 33-7
AB  - BACKGROUND: Psychosis in pediatric mood disorder patients may be related to 
      suicidal ideation. Bipolar (BP) adolescents are at high risk of completed 
      suicide. We examined whether pediatric BP patients with psychosis have a higher 
      prevalence of suicidality than non-psychotic BP patients. Based on previous 
      findings in adult BP patients, we predicted that pediatric BP patients with 
      psychotic symptoms would have higher prevalence of suicidality, higher occurrence 
      of lifetime psychiatric hospitalizations and worse current Global Assessment of 
      Functioning Scale (GAF) scores compared to non-psychotic BP patients. METHODS: We 
      studied 43 BP children and adolescents (mean age +/- S.D = 11.2 +/- 2.8 y, range 
      = 8-17) who did (n = 17) or did not have (n = 26) a lifetime history of psychotic 
      symptoms. Indicators of suicidality (thoughts of death and suicidal ideation, 
      plans, and attempts), psychiatric diagnoses, psychotic symptoms, psychiatric 
      hospitalizations and GAF scores were assessed with the K-SADS-PL interview. 
      LIMITATIONS: Small sample size, cross-sectional study and exclusion of substance 
      abuse comorbidity. RESULTS: Pediatric BP patients with a lifetime history of 
      psychotic symptoms compared to BP patients without psychosis were more likely to 
      have thoughts of death (100% versus 69.2%, p = 0.01), suicidal ideation (94.1% 
      versus 42.3%, p = 0.001) and suicidal plans (64.7% versus 15.4%, p = 0.002). 
      Occurrence of psychiatric hospitalization was higher in psychotic BP patients 
      compared to non-psychotic BP patients (82.4% versus 46.2%, p = 0.018). 
      CONCLUSIONS: Psychotic symptoms in pediatric BP patients are associated with 
      suicidal ideation and plans, and psychiatric hospitalizations. Psychotic symptoms 
      are a risk factor for suicidality amongst pediatric BP patients.
FAU - Caetano, Sheila C
AU  - Caetano SC
AD  - Department of Psychiatry, The University of Texas Health Science Center at San 
      Antonio, San Antonio, TX 78229, USA.
FAU - Olvera, Rene L
AU  - Olvera RL
FAU - Hunter, Kristina
AU  - Hunter K
FAU - Hatch, John P
AU  - Hatch JP
FAU - Najt, Pablo
AU  - Najt P
FAU - Bowden, Charles
AU  - Bowden C
FAU - Pliszka, Steven
AU  - Pliszka S
FAU - Soares, Jair C
AU  - Soares JC
LA  - eng
GR  - M01-RR-01346/RR/NCRR NIH HHS/United States
GR  - MH01736/MH/NIMH NIH HHS/United States
GR  - MH69774/MH/NIMH NIH HHS/United States
GR  - RR020571/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060127
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adolescent
MH  - Bipolar Disorder/*epidemiology/psychology
MH  - Child
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Patient Admission/statistics & numerical data
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*epidemiology/psychology
MH  - Risk Factors
MH  - Statistics as Topic
MH  - Suicide, Attempted/psychology/*statistics & numerical data
EDAT- 2006/02/01 09:00
MHDA- 2006/10/05 09:00
CRDT- 2006/02/01 09:00
PHST- 2005/05/26 00:00 [received]
PHST- 2005/11/11 00:00 [revised]
PHST- 2005/12/07 00:00 [accepted]
PHST- 2006/02/01 09:00 [pubmed]
PHST- 2006/10/05 09:00 [medline]
PHST- 2006/02/01 09:00 [entrez]
AID - S0165-0327(05)00378-2 [pii]
AID - 10.1016/j.jad.2005.12.008 [doi]
PST - ppublish
SO  - J Affect Disord. 2006 Mar;91(1):33-7. doi: 10.1016/j.jad.2005.12.008. Epub 2006 
      Jan 27.