PMID- 16446742
OWN - NLM
STAT- MEDLINE
DCOM- 20060731
LR  - 20220129
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 11
IP  - 5
DP  - 2006 May
TI  - The brain-derived neurotrophic factor Val66Met polymorphism is associated with 
      age-related change in reasoning skills.
PG  - 505-13
AB  - A polymorphism (Val66Met) in the gene encoding brain-derived neurotrophic factor 
      (BDNF) has previously been associated with impaired hippocampal function and 
      scores on the Logical Memory subtest of the Wechsler Memory Scale-Revised 
      (WMS-R). Despite its widespread expression in the brain, there have been few 
      studies examining the role of BDNF on cognitive domains, other than memory. We 
      examined the association between BDNF Val66Met genotype and non-verbal reasoning, 
      as measured by Raven's standard progressive matrices (Raven), in two cohorts of 
      relatively healthy older people, one aged 79 (LBC1921) and the other aged 64 
      (ABC1936) years. LBC1921 and ABC1936 subjects had reasoning measured at age 11 
      years, using the Moray House Test (MHT), in the Scottish Mental Surveys of 1932 
      and 1947, respectively. BDNF genotype was significantly associated with later 
      life Raven scores, controlling for sex, age 11 MHT score and cohort (P = 0.001). 
      MHT, Verbal Fluency and Logical Memory scores were available, in later life, for 
      LBC1921 only. BDNF genotype was significantly associated with age 79 MHT score, 
      controlling for sex and age 11 MHT score (P = 0.016). In both significant 
      associations, Met homozygotes scored significantly higher than heterozygotes and 
      Val homozygotes. This study indicates that BDNF genotype contributes to 
      age-related changes in reasoning skills, which are closely related to general 
      intelligence.
FAU - Harris, S E
AU  - Harris SE
AD  - Department of Psychology, University of Edinburgh, Edinburgh, UK. 
      Sarah.Harris@hgu.mrc.ac.uk
FAU - Fox, H
AU  - Fox H
FAU - Wright, A F
AU  - Wright AF
FAU - Hayward, C
AU  - Hayward C
FAU - Starr, J M
AU  - Starr JM
FAU - Whalley, L J
AU  - Whalley LJ
FAU - Deary, I J
AU  - Deary IJ
LA  - eng
GR  - MC_U127561128/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Cognition/*physiology
MH  - Cohort Studies
MH  - Follow-Up Studies
MH  - Genetics, Behavioral
MH  - Geriatric Assessment
MH  - Humans
MH  - Intelligence/*physiology
MH  - Polymorphism, Single Nucleotide
MH  - Population Surveillance
MH  - Problem Solving/*physiology
MH  - Reference Values
MH  - Wechsler Scales
EDAT- 2006/02/01 09:00
MHDA- 2006/08/01 09:00
CRDT- 2006/02/01 09:00
PHST- 2006/02/01 09:00 [pubmed]
PHST- 2006/08/01 09:00 [medline]
PHST- 2006/02/01 09:00 [entrez]
AID - 4001799 [pii]
AID - 10.1038/sj.mp.4001799 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2006 May;11(5):505-13. doi: 10.1038/sj.mp.4001799.