PMID- 16447919
OWN - NLM
STAT- MEDLINE
DCOM- 20060223
LR  - 20190117
IS  - 1726-4901 (Print)
IS  - 1726-4901 (Linking)
VI  - 69
IP  - 1
DP  - 2006 Jan
TI  - Comparison of the skin test and ImmunoCAP system in the evaluation of mold 
      allergy.
PG  - 3-6
AB  - BACKGROUND: Mold is ubiquitous in our environment and is a common allergen in 
      allergic diseases. The skin test and the Pharmacia ImmunoCAP system (CAP) for 
      assay-specific immunoglobulin E (IgE) antibodies are both widely used. The goal 
      of this study was to compare the performance of the skin test and CAP in the 
      evaluation of mold allergy. METHODS: Patients with allergic rhinitis were 
      enrolled at our outpatient department. The diagnosis of allergic rhinitis was 
      based on typical symptoms for more than 2 years. All patients were tested by both 
      intradermal skin test and serum assay for specific IgE antibodies. The skin test 
      included house dust, cotton, ragweed, and 5 fungal antigens (Candida, Alternaria, 
      Aspergillus, Cladosporium, and Penicillium). The serum-specific IgE antibodies 
      were quantified using the radioimmunoassay version of CAP. RESULTS: Seventy-five 
      patients (44 males and 31 females) with allergic rhinitis were enrolled in this 
      study. Their ages ranged from 12 to 76 years old, with a mean of 31.9 years. The 
      positive rates of skin test and CAP were 56.0% versus 9.3% for Candida, 22.7% 
      versus 1.3% for Alternaria, 16% versus 9.3% for Aspergillus, 14.7% versus 1.3% 
      for Cladosporium, and 32% versus 8% for Penicillium. There were statistically 
      significant differences between the positive rates for Candida, Alternaria, 
      Cladosporium, and Penicillium when analyzed by the McNemar test. CONCLUSION: The 
      positive rate of the skin test is higher than CAP when evaluating mold allergy. 
      Clinicians should note that a discrepancy may exist between the results of in 
      vitro and in vivo tests when evaluating mold allergy.
FAU - Liang, Kai-Li
AU  - Liang KL
AD  - Department of Otolaryngology, Taichung Veterans General Hospital, Taiwan, ROC.
FAU - Su, Mao-Chang
AU  - Su MC
FAU - Jiang, Rong-San
AU  - Jiang RS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - J Chin Med Assoc. 2006 Jan;69(1):1-2. PMID: 16447918
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Female
MH  - Fungi/*immunology
MH  - Humans
MH  - Hypersensitivity/*diagnosis
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Skin Tests/*methods
EDAT- 2006/02/02 09:00
MHDA- 2006/02/24 09:00
CRDT- 2006/02/02 09:00
PHST- 2006/02/02 09:00 [pubmed]
PHST- 2006/02/24 09:00 [medline]
PHST- 2006/02/02 09:00 [entrez]
AID - S1726-4901(09)70103-0 [pii]
AID - 10.1016/S1726-4901(09)70103-0 [doi]
PST - ppublish
SO  - J Chin Med Assoc. 2006 Jan;69(1):3-6. doi: 10.1016/S1726-4901(09)70103-0.