PMID- 16448701
OWN - NLM
STAT- MEDLINE
DCOM- 20061004
LR  - 20090928
IS  - 0165-0327 (Print)
IS  - 0165-0327 (Linking)
VI  - 91
IP  - 1
DP  - 2006 Mar
TI  - Effect of repetitive transcranial magnetic stimulation on serum brain derived 
      neurotrophic factor in drug resistant depressed patients.
PG  - 83-6
AB  - BACKGROUND: Depression has been associated with low brain-derived neurotrophic 
      factor (BDNF) serum levels, while antidepressant drugs appear to mend this 
      alteration. The purpose of this study was to assess BDNF serum levels in drug 
      resistant depressed patients before and after repetitive Transcranial Magnetic 
      Stimulation (rTMS) antidepressant treatment. METHODS: BDNF levels were measured 
      in serum of 16 resistant depressed patients using the ELISA technique. RESULTS: 
      BDNF baseline levels showed a negative correlation with illness severity measured 
      by HDRS scores (R = -0.517, p = 0.04) and a significant increase of serum BDNF 
      was found after rTMS treatment (t = -2.549, df = 15, p = 0.022). CONCLUSIONS: Our 
      findings support the relationship between decreased serum BDNF and depression 
      symptomatology and suggest a normalizing effect of rTMS antidepressant treatment. 
      Further replications in larger samples will help to clarify the relevance of this 
      preliminary data in the rTMS mechanism of action.
FAU - Zanardini, Roberta
AU  - Zanardini R
AD  - IRCCS "S. Giovanni di Dio", Fatebenefratelli, Brescia, Italy.
FAU - Gazzoli, Anna
AU  - Gazzoli A
FAU - Ventriglia, Mariacarla
AU  - Ventriglia M
FAU - Perez, Jorge
AU  - Perez J
FAU - Bignotti, Stefano
AU  - Bignotti S
FAU - Rossini, Paolo Maria
AU  - Rossini PM
FAU - Gennarelli, Massimo
AU  - Gennarelli M
FAU - Bocchio-Chiavetto, Luisella
AU  - Bocchio-Chiavetto L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060131
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cerebral Cortex/physiopathology
MH  - Depressive Disorder, Major/*blood/*therapy
MH  - Drug Resistance
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Personality Inventory
MH  - Statistics as Topic
MH  - *Transcranial Magnetic Stimulation
MH  - Treatment Outcome
EDAT- 2006/02/02 09:00
MHDA- 2006/10/05 09:00
CRDT- 2006/02/02 09:00
PHST- 2005/08/11 00:00 [received]
PHST- 2005/12/09 00:00 [revised]
PHST- 2005/12/14 00:00 [accepted]
PHST- 2006/02/02 09:00 [pubmed]
PHST- 2006/10/05 09:00 [medline]
PHST- 2006/02/02 09:00 [entrez]
AID - S0165-0327(05)00416-7 [pii]
AID - 10.1016/j.jad.2005.12.029 [doi]
PST - ppublish
SO  - J Affect Disord. 2006 Mar;91(1):83-6. doi: 10.1016/j.jad.2005.12.029. Epub 2006 
      Jan 31.