PMID- 16448704
OWN - NLM
STAT- MEDLINE
DCOM- 20060525
LR  - 20061115
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 104
IP  - 1-2
DP  - 2006 Apr 15
TI  - Expression and role of Fc- and complement-receptors on human dendritic cells.
PG  - 46-52
AB  - Dendritic cells (DCs) are professional antigen presenting cells, which take up 
      pathogens/foreign structures in peripheral tissues, then migrate to secondary 
      lymphoid organs where they initiate adaptive immune responses by activating naive 
      T-cells. In the early phase of antigen uptake pattern recognition receptors 
      (including mannose-, scavenger- and toll-like receptors) that recognize 
      pathogen-associated molecular patterns play an important role. Later receptors 
      binding opsonized antigen are also involved in phagocytosis. These cell membrane 
      molecules include various Fc-receptors, recognizing different isotypes of 
      antibodies and various complement-receptors, such as CR3, CR4 and the C1q-binding 
      complex of calreticulin and CD91. Here we aim to summarize how these 
      immunecomplex binding receptors are involved in the initiation of DC maturation, 
      and how they influence antigen presentation as well as some additional functions 
      of these cells.
FAU - Bajtay, Zsuzsa
AU  - Bajtay Z
AD  - Department of Immunology, Eotvos Lorand University, Pazmany Peter s. 1/C, 
      Budapest H-1117, Hungary.
FAU - Csomor, Eszter
AU  - Csomor E
FAU - Sandor, Noemi
AU  - Sandor N
FAU - Erdei, Anna
AU  - Erdei A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20051213
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Immunoglobulins)
RN  - 0 (Receptors, Complement)
RN  - 0 (Receptors, Fc)
SB  - IM
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunoglobulins/immunology
MH  - Receptors, Complement/*metabolism
MH  - Receptors, Fc/*metabolism
RF  - 76
EDAT- 2006/02/02 09:00
MHDA- 2006/05/26 09:00
CRDT- 2006/02/02 09:00
PHST- 2005/11/16 00:00 [received]
PHST- 2005/11/22 00:00 [revised]
PHST- 2005/11/22 00:00 [accepted]
PHST- 2006/02/02 09:00 [pubmed]
PHST- 2006/05/26 09:00 [medline]
PHST- 2006/02/02 09:00 [entrez]
AID - S0165-2478(05)00368-8 [pii]
AID - 10.1016/j.imlet.2005.11.023 [doi]
PST - ppublish
SO  - Immunol Lett. 2006 Apr 15;104(1-2):46-52. doi: 10.1016/j.imlet.2005.11.023. Epub 
      2005 Dec 13.